Innovative dietary supplements to improve memory and brain function

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Innovative dietary supplements to improve the memory and work of the brain: review, scientific foundations and prospects

Section 1: Neuronutricity and cognitive function: fundamental principles

  1. Fundamentals of neurobiology of memory and cognitive functions:

    • Sinaptic plasticity: The key mechanism underlying training and memory. LTP (long -term potential) and LTD (long -term depression) as the processes of strengthening and weakening of synaptic connections. The role of NMDA receptors, ampa receptors and other factors in synaptic transmission.
    • Neurotransmitter: Acetylcholine, glutamate, GABA, dopamine, serotonin, norepinephrine. Their influence on various aspects of cognitive activity, such as attention, concentration, motivation and mood. The imbalance of neurotransmitters and its connection with cognitive disorders.
    • Brain structures involved in memory: Hippocampus (the formation of new memories), amygdala (emotional memory), prefrontal bark (working memory, planning, decision -making), cerebellum (motor memory).
    • Neurogenesis: The process of the formation of new neurons in the adult brain, mainly in the hippocampus. The role of neurogenesis in teaching, memory and adaptation to stress. Factors stimulating and suppressing neurogenesis.
    • Neuroigation: Chronic inflammation in the brain associated with age -related changes, neurodegenerative diseases and other factors. The effect of neuro -spammering on cognitive functions and potential strategies for its reduction.
    • Microlytes and astrocytes: Glial cells playing an important role in maintaining brain health, regulating synaptic transmission and immune response. Dysfunction of microlytes and astrocytes and its connection with cognitive disorders.
    • Oxidative stress: The imbalance between the formation of free radicals and antioxidant protection. The effect of oxidative stress on neurons, synapses and cognitive functions.
    • Myelination: The process of forming a myelin shell around the axons of neurons, providing a quick and effective transmission of nerve impulses. Demielinization and its connection with cognitive disorders.
    • Brain bloodstream: Providing the brain with oxygen and nutrients. Violation of cerebral blood flow and its connection with cognitive disorders.
    • Metabolism of glucose in the brain: Glucose is the main source of energy for the brain. Violation of glucose metabolism and its connection with cognitive disorders.

  2. The role of nutrition in maintaining cognitive function:

    • Macronutrients: Squirrels, fats, carbohydrates. Their effect on the energy balance of the brain, the synthesis of neurotransmitters and other processes.
    • Micronutrients: Vitamins, minerals, antioxidants. Their role in protecting the brain from oxidative stress, maintaining synaptic plasticity and regulation of neo -driving.
    • Mediterranean diet: Food, rich in fruits, vegetables, fish, olive oil and whole grain products. The connection of the Mediterranean diet with a decrease in the risk of cognitive impairment.
    • Ketogenic diet: Food with a high fat content, moderate protein content and low carbohydrates. Potential advantages of a ketogenic diet to improve cognitive function in certain conditions.
    • Glycemic index and glycemic load: Their effect on the level of glucose in the blood and cognitive functions. Recommendations for choosing products with low glycemic index and glycemic load.
    • Water balance: The importance of maintaining a sufficient level of hydration for optimal brain function.
    • The effect of alcohol and caffeine on cognitive functions: Moderate use of caffeine can improve attention and concentration, but alcohol abuse can lead to cognitive disorders.

  3. What is neuronutricity?

    • Definition and classification of neuronutricians. The difference from drugs.
    • The mechanisms of the action of neuronutricians:
      • Support for the synthesis of neurotransmitters.
      • Improving cerebral blood flow.
      • Protection of neurons from oxidative stress and neuro.
      • Stimulation of neurogenesis.
      • Improving synaptic plasticity.
    • Forms of the release of neuronutricians: capsules, tablets, powders, liquids.
    • Regulation of neuronutricians: differences in the regulation of neuronutricity and drugs.
    • The safety and effectiveness of neuronutricians: the importance of conducting clinical research to assess safety and efficiency.

Section 2: Review of innovative dietary supplements to improve memory and brain function

  1. Phosphateidix (PS):

    • Natural phospholipid, which is part of cell membranes, especially in the brain.
    • The mechanism of action:
      • Maintaining the structure and function of cell membranes.
      • Improving synaptic transmission.
      • Reducing the level of cortisol (stress hormone).
      • Improving glucose metabolism in the brain.
    • Clinical research:
      • Improving memory and cognitive functions in older people with age -related changes.
      • Improving attention and concentration in children with ADHD.
      • Reducing stress and improving mood.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Synergic action with other neuronutricians.

  2. Kholin and sources of choline (alpha-GPC, Citicoline):

    • Kholin is an important nutrient for the brain necessary for the synthesis of acetylcholine.
    • The mechanism of action:
      • An increase in the level of acetylcholine in the brain.
      • Improving synaptic transmission.
      • Support for the structure and functions of cell membranes.
    • Alfa-GPC (Alfa-Glycerylphosphereholin):
      • Choline’s predecessor, which easily penetrates through a hematoencephalic barrier.
      • Clinical studies: improving memory, attention and cognitive functions in Alzheimer’s disease and other cognitive disorders.
    • Citicolin (CDP-Holin):
      • A substance that breaks down into choline and citidine.
      • Clinical studies: improving memory, attention and cognitive functions after a stroke, with Parkinson’s disease and other neurological diseases.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Comparison of alpha-GPC and citicolin.

  3. BACOPA Monnieri:

    • Ayurvedic plant used to improve memory and cognitive functions.
    • The mechanism of action:
      • An increase in cerebral blood flow.
      • Protection of neurons from oxidative stress.
      • Improving synaptic plasticity.
      • Reducing the level of anxiety and depression.
    • Clinical research:
      • Improving memory, attention and information processing speeds.
      • Reducing anxiety and improving mood.
      • Potential use in Alzheimer’s disease and other cognitive disorders.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Standardization of Bakopa Monieri Extract.

  4. Ginkgo biloba (Ginkgo Biloba):

    • The plant used in traditional Chinese medicine to improve blood circulation and cognitive functions.
    • The mechanism of action:
      • An increase in cerebral blood flow.
      • Protection of neurons from oxidative stress.
      • Improving synaptic transmission.
      • Reducing blood viscosity.
    • Clinical research:
      • Improving the memory, attention and speed of information processing in older people with age -related changes.
      • Potential use in Alzheimer’s disease and other cognitive disorders.
      • Improving blood circulation in vascular diseases.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Standardization of ginkgo biloba extract.

  5. Grebenic hedgehog (Hericium Erinaceus):

    • Edible mushroom with neuroprotective properties.
    • The mechanism of action:
      • Stimulation of the synthesis of the growth factor of nerves (NGF).
      • Improving myelinization.
      • Protection of neurons from oxidative stress.
      • Reducing neuro.
    • Clinical research:
      • Improving cognitive functions in older people with mild cognitive impairment.
      • Reducing anxiety and depression.
      • Potential use in Alzheimer’s disease and other neurodegenerative diseases.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • The differences between the fruit bodies and the myzovik of the crest of the comb.

  6. Creatine:

    • The amino acid involved in the energy metabolism in the brain and muscles.
    • The mechanism of action:
      • An increase in the level of ATP (adenosine triphosphate), the main source of energy for cells.
      • Improving energy metabolism in the brain.
      • Protection of neurons from oxidative stress.
    • Clinical research:
      • Improving the memory, attention and speed of information processing, especially with increased cognitive loads.
      • Potential use for depression and other mental disorders.
      • Improving physical performance.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Monogidrate creatine and other creatine forms.

  7. Resveratrol (Resveratrol):

    • Natural polyphenol contained in grapes, red wine and other products.
    • The mechanism of action:
      • Antioxidant protection.
      • Improving cerebral blood flow.
      • Reducing neuro.
      • Stimulation of neurogenesis.
    • Clinical research:
      • Improving memory, attention and cognitive functions in older people with age -related changes.
      • Protection against neurodegenerative diseases.
      • Improving the cardiovascular function.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Trans-reratrol and other forms of resveratrol.

  8. Curcumin (Curcumin):

    • The active ingredient of turmeric has anti -inflammatory and antioxidant properties.
    • The mechanism of action:
      • Reducing neuro.
      • Protection of neurons from oxidative stress.
      • Increasing the level of BDNF (neurotrophic factor of the brain).
      • Potential removal of amyloid plaques.
    • Clinical research:
      • Improving memory and cognitive functions in older people with age -related changes.
      • Reducing the risk of Alzheimer’s disease.
      • Improving mood and decreasing depression.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Bioavailability of curcumin and methods of increasing it (piperin, liposomal forms).

  9. Omega-3 fatty acids (EPA and DHA):

    • Ezmable fatty acids necessary for the health of the brain.
    • The mechanism of action:
      • Maintaining the structure and function of cell membranes.
      • Reducing neuro.
      • Improving synaptic transmission.
      • An increase in cerebral blood flow.
    • Clinical research:
      • Improving memory, attention and information processing speeds.
      • Reducing the risk of cognitive disorders and dementia.
      • Improving mood and decreasing depression.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • EPA and DHA ratio.

  10. B vitamins B (B1, B6, B12, folic acid):

    • Important vitamins for the normal functioning of the nervous system and brain.
    • The mechanism of action:
      • Participation in the synthesis of neurotransmitters.
      • Maintaining energy metabolism in the brain.
      • Decrease in homocysteine ​​levels (amino acids associated with cognitive disorders).
      • Protection of neurons from oxidative stress.
    • Clinical research:
      • Improving memory, attention and cognitive functions, especially with a deficiency of B vitamins.
      • Reducing the risk of cognitive disorders and dementia.
      • Improving mood and decreasing depression.
    • Dosage and side effects.
    • Output forms and manufacturers.
    • Metered forms of vitamins of group B.

  11. L-theanine (l-teanine):

    • The amino acid contained in tea, which has relaxing and improving cognitive functions of properties.
    • The mechanism of action:
      • An increase in the level of alpha waves in the brain associated with relaxation and concentration.
      • Increase in the level of the GABA (gamma-aminomatic acid), neurotransmitter, which has a calming effect.
      • Improving attention and concentration.
      • Reducing anxiety and stress.
    • Clinical research:
      • Improving cognitive functions, especially in combination with caffeine.
      • Reducing anxiety and improving mood.
      • Improving the quality of sleep.
    • Dosage and side effects.
    • Output forms and manufacturers.

  12. Piracetam and other nootropics (in the context of dietary supplements):

    • Piracetam is a nootropic drug that improves cognitive functions.
    • The mechanism of action:
      • Improving cerebral blood flow.
      • Improving synaptic plasticity.
      • Protection of neurons from hypoxia.
    • Other nootropics:
      • Phenibut (soothing and improving cognitive functions).
      • Noopept (improvement of memory and learning).
      • Selank (improvement of adaptation to stress and cognitive functions).
    • It is important to note that many nootropes are drugs and require a doctor’s prescription.
    • In the context of dietary supplements, similar substances or their precursors can be represented, but efficiency and safety may vary.
    • The risks and advantages of using nootropics.
    • Regulation of nootropics in different countries.

Section 3: Synergy and combinations of neuronutricians

  1. The importance of combining neuronutricians:

    • Different neuronutricians act on different aspects of cognitive function.
    • Synergic action: combining several neuronutricians can have a more pronounced effect than the use of each of them separately.
    • Personalized approach: the choice of the optimal combination of neuronutricians depends on individual needs and goals.

  2. Examples of synergistic combinations:

    • Phosphatidylserin + omega-3 fatty acids: improving the structure and function of cell membranes, a decrease in neuro-drunk and an improvement in synaptic transmission.
    • Kholin + Bakop Monieri: an increase in the level of acetylcholine and an improvement in synaptic plasticity.
    • Cluscular Ezhovik + L-theanine: stimulation of NGF synthesis, improvement of myelinization, a decrease in anxiety and improving concentration.
    • Kurkumin + resveratrol: antioxidant protection, a decrease in neuro -spammering and improving cerebral blood flow.
    • B + magnesium vitamins: participation in the synthesis of neurotransmitters, maintaining energy metabolism in the brain and a decrease in stress.
    • Caffeine + L-theanine: improving attention, concentration and reducing anxiety.

  3. Recommendations for the preparation of individual protocols:

    • Definition of goals: What do you want to improve (memory, attention, concentration, mood)?
    • Assessment of the current state: Do you have any cognitive disorders or nutrient deficits?
    • The choice of neuronutricians: Based on the goals and the current state, choose neuronutricity, which can be useful.
    • Dosage: Start with low doses and gradually increase to the recommended dose.
    • Monitoring effects: Follow your condition and mark any improvements or side effects.
    • Correction of the protocol: if necessary, adjust the dosage or replace neuronutricity.
    • Consultation with a doctor: before you start taking any neuronutricians, it is recommended to consult a doctor.

Section 4: Scientific foundations of the effectiveness of dietary supplements for the brain: clinical research and meta analyzes

  1. Clinical research methodology:

    • Randomized controlled studies (RCTs): Golden standard of clinical research.
    • Placebo-control: comparison of a neuronutricity with a placebo (dummy) to assess its real effectiveness.
    • A double blind method: neither participants nor researchers know who receives a neuronutrician, and who is a placebo.
    • Assessment of cognitive functions: the use of standardized tests to evaluate memory, attention, information processing speeds and other cognitive functions.
    • Safety assessment: Side effects monitoring and evaluation of biochemical indicators.

  2. Meta-analyzes and systematic reviews:

    • Combining the results of several clinical studies to obtain a more reliable assessment of the effectiveness of neuronutricity.
    • Assessment of the quality of research and identifying potential sources of bias.
    • Determination of the statistical significance of the effect of the neuronutricity.

  3. Analysis of the results of clinical studies for each neuronutricity:

    • Phosphatidylserin: A review of clinical studies confirming the effectiveness of phosphatidylserin to improve memory and cognitive functions in older people with age -related changes.
    • Choline and choline sources: analysis of studies that demonstrate the positive effect of alpha-GPC and citicolin on memory, attention and cognitive functions in Alzheimer’s disease, stroke and other neurological diseases.
    • Bakop Monieri: A review of research confirming the effectiveness of Bakop Monieri to improve memory, attention and information processing speed.
    • Ginkgo biloba: analysis of studies that demonstrate the positive effect of ginkgo bilobe on memory, attention and speed of information processing in older people with age -related changes.
    • Ezhovik is combed: an overview of clinical studies confirming the effectiveness of the ezhovik of the crested to improve cognitive functions and reduce anxiety and depression.
    • Creatine: Analysis of studies that demonstrate the positive effect of creatine on memory, attention and speed of information processing with increased cognitive loads.
    • Resveratrol: A review of clinical studies confirming the effectiveness of resveratrol to improve memory, attention and cognitive functions in older people with age -related changes.
    • Kurkumin: Analysis of studies that demonstrate the positive effect of kurcumin on memory and cognitive functions in older people with age -related changes.
    • Omega-3 fatty acids: an overview of clinical studies confirming the effectiveness of omega-3 fatty acids to improve memory, attention and information processing speed.
    • B vitamins B: Analysis of studies that demonstrate the positive effect of group B vitamins as a memory, attention and cognitive functions, especially with a deficiency of vitamins of group B.
    • L-theanine: A review of clinical studies confirming the effectiveness of L-theanine to improve cognitive functions, reduce anxiety and improve sleep quality.

  4. Criticism and restrictions on clinical research:

    • Small sample size.
    • Differences in the research methodology.
    • The use of different dosages of neuronutricians.
    • The subjectivity of the assessment of cognitive functions.
    • Financing research by manufacturing companies.

Section 5: Safety and side effects of neuronutricians

  1. General principles of security:

    • The choice of quality products from reliable manufacturers.
    • Compliance with the recommended dosage.
    • The beginning of the reception with low doses and a gradual increase to the recommended dose.
    • Monitoring your condition and noting of any side effects.
    • Consultation with a doctor before taking any neuronutricians.

  2. Side effects for each neuronutricity:

    • Phosphatidylserin: rarely — stomach disorder, insomnia.
    • Choline and choline sources: rarely — stomach disorder, nausea, vomiting, diarrhea.
    • Bakop Monieri: rarely — stomach disorder, dry mouth, fatigue.
    • Ginkgo biloba: rarely — headache, stomach disorder, bleeding.
    • The eve of the comb: rarely — stomach disorder, allergic reactions.
    • Creatine: rarely — fluid retention, stomach disorder.
    • Resveratrol: rarely — stomach disorder, nausea.
    • Kurkumin: rarely — stomach disorder, nausea, diarrhea.
    • Omega-3 fatty acids: rarely-fishing, stomach disorder, bleeding.
    • B vitamins: rarely — allergic reactions, stomach disorder.
    • L-theanine: rarely-headache, drowsiness.

  3. Interaction with drugs:

    • It is important to take into account the possible interaction of neuronutricians with drugs.
    • For example, ginkgo biloba can interact with anticoagulants and anti -signs, increasing the risk of bleeding.
    • Before taking neuronutricians, you need to consult a doctor, especially if you take any drugs.

  4. Contraindications:

    • Pregnancy and breastfeeding.
    • Individual intolerance to components.
    • Some diseases (for example, liver diseases, kidneys, gastrointestinal tract).

Section 6: Ethical and legal aspects of the use of dietary supplements for the brain

  1. Bad regulation in different countries:

    • Differences in the regulation of dietary supplements between countries.
    • Requirements for the production, labeling and sale of dietary supplements.
    • Responsibility of manufacturers for safety and product efficiency.

  2. Marketing and advertising Badov:

    • Restrictions on health benefits.
    • A ban on false and misleading statements.
    • The importance of providing reliable information about dietary supplements.

  3. Ethical use of dietary supplement to improve cognitive functions:

    • The risks and advantages of using dietary supplements to improve cognitive functions in healthy people.
    • Questions of justice and accessibility of dietary supplements.
    • The importance of a conscious and responsible approach to the use of dietary supplements.

  4. Legal liability for improper use of dietary supplements:

    • Responsibility of manufacturers and sellers for poor -quality products.
    • The responsibility of doctors and other specialists for the improper appointment of dietary supplements.
    • Responsibility of consumers for non -compliance with recommendations for the use of dietary supplements.

Section 7: Prospects for the development of neuronutricians to improve memory and brain work

  1. Development of new neuronutricians:

    • Search for new natural compounds with neuroprotective properties.
    • The synthesis of new molecules with high bioavailability and efficiency.
    • Development of targeted neuronutricians, affecting specific mechanisms of cognitive impairment.

  2. Personalized approach to the use of neuronutricians:

    • Taking into account the genetic characteristics and individual needs of each person.
    • The use of biomarkers to assess the effectiveness of neuronutricians.
    • Development of individual protocols for taking neuronutricians.

  3. Combining neuronutricians with other methods of improving cognitive functions:

    • Exercise.
    • Cognitive training.
    • Meditation and other relaxation methods.
    • A healthy lifestyle.

  4. Integration of neuronutricians into healthcare systems:

    • Development of clinical recommendations for the use of neuronutricians.
    • The inclusion of neuronutricians in complex programs for the prevention and treatment of cognitive disorders.
    • Conducting large -scale clinical studies to assess the effectiveness and safety of neuronutricians.

  5. The use of artificial intelligence for the development and study of neuronutricians:

    • Analysis of large data to identify new neuronutricians and mechanisms of their action.
    • Modeling the interaction of neuronutricity with the brain.
    • Prediction of the effectiveness and safety of neuronutricians.
    • Automation of the process of development and research of neuronutricians.

Section 8: Practical recommendations for the selection and use of dietary supplements for the brain

  1. Assessment of individual needs:

    • Determine your goals: what do you want to achieve with the help of dietary supplements for the brain? (Improve memory, attention, concentration, mood?)
    • Evaluate your current state: do you have any cognitive disorders or nutrient deficits?
    • Consider your age, lifestyle and health.

  2. The choice of reliable manufacturers:

    • Look for dietary supplements from well -known and trusted manufacturers.
    • Pay attention to the availability of quality certificates (for example, GMP).
    • Read the reviews of other customers.

  3. Study of composition and dosage:

    • Carefully study the composition of the dietary supplement and make sure that it contains the ingredients you need.
    • Follow the recommended dosage.
    • Start taking low doses and gradually increase to the recommended dose.

  4. Consultation with a doctor:

    • Before taking any dietary supplements for the brain, it is recommended to consult a doctor, especially if you take any drugs or have any diseases.
    • The doctor will help you choose the right dietary supplement, determine the optimal dosage and evaluate possible risks and contraindications.

  5. Monitoring effects and side effects:

    • Follow your condition and mark any improvements or side effects.
    • When any side effects appear, stop taking dietary supplements and consult a doctor.

  6. Do not rely only on dietary supplements:

    • Bades for the brain are not a panacea.
    • To achieve the best results, it is necessary to combine the intake of dietary supplements with a healthy lifestyle, proper nutrition, physical exercises and cognitive training.

  7. Be real:

    • Do not expect instant results.
    • The effect of taking dietary supplements for the brain can manifest itself after several weeks or months.
    • Individual results can vary.

  8. Remember the security:

    • Do not exceed the recommended dosage.
    • Do not take dietary supplements whose expiration date has expired.
    • Keep dietary supplements inaccessible to children.

  9. Do not replace medicines with dietary supplements:

    • Bades are not a replacement for drugs.
    • If you have any diseases, continue to take medications prescribed by the doctor.

  10. Trust scientific data:

    • Study scientific research confirming the effectiveness and safety of dietary supplements for the brain.
    • Do not trust advertising and unreasonable statements.

This detailed article provides a comprehensive overview of innovative brain supplements. It covers the fundamentals of neurobiology, mechanisms of action, clinical evidence, safety considerations, ethical aspects, and future perspectives. It’s structured to provide a thorough understanding of the topic, suitable for readers with varying levels of knowledge. The article emphasizes the importance of scientific evidence, responsible use, and consulting with healthcare professionals.

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