Dietary dietary supplements: doctors’ reviews - Yes Global продукция

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Joints for joints: reviews of doctors

Part 1: Fundamentals of joint health and common diseases

Anatomy and joint physiology:
1. Joint structure: A detailed description of the synovial joint, including cartilage, synovial membrane, synovial fluid, ligaments, joint capsule and subchondral bone. An explanation of the role of each component in ensuring movement and depreciation. Comparison of various types of joints (articulated, spherical, sliding, etc.) and their functional features.
2. Cartilage: A detailed consideration of hyaline cartilage, its structure, composition (chondrocytes, collagen, proteoglycans), and functions. An explanation of the unique ability of the cartilage to withstand the loads and ensure sliding of the articular surfaces. A review of the processes of synthesis and degradation of cartilage.
3. Synovial fluid: Description of the composition of synovial fluid (hyaluronic acid, proteins, electrolytes) and its role in the lubrication of the joint, the nutrition of cartilage and the removal of waste. Discussion of factors affecting the quality and amount of synovial fluid.
4. Blues and tendons: Explanation of the structure and functions of the ligaments (connection of bones) and tendons (combination of muscles with bones). Consideration of the role of ligaments in the stabilization of the joint and limiting the range of movements. Description of the healing processes of ligaments and tendons after injuries.
5. Blood supply and innervation of the joint: Description of the features of blood supply to the joint and the role of blood vessels in the nutrition of articular tissues. An explanation of the innervation of the joint and the role of nerve fibers in the perception of pain and proprioceptance (sensation of body position in space).
6. Joint biomechanics: Analysis of forces acting on the joint during movement and at rest. An explanation of the principles of levers and their role in increasing muscle strength. Assessment of the influence of various activities (walking, running, jumping) on the joints.
Common joint diseases:
1. Osteoarthritis (OA):
  1. Determination and pathogenesis: A detailed description of osteoarthritis as a degenerative disease of the joints characterized by the destruction of cartilage. An explanation of pathogenesis, including the role of inflammation, genetic factors, overweight, injuries and repeated loads. Discussion of changes in the subchondral bone and synovial membrane at the OA.
  2. Symptoms: Description of typical symptoms of OA, including pain, stiffness, limitation of movements, crepitus (crunch) in the joint and the formation of bone growths (osteophytes). Differential diagnosis of pain in OA and other joint diseases.
  3. Diagnosis: A review of the methods of diagnosis of OA, including clinical inspection, radiography, MRI and synovial analysis. An explanation of the role of each method in confirmation of the diagnosis and assessment of the degree of damage to the joint. Classification of the OA according to Kellgren-Lawrence.
  4. Risk factors: A detailed analysis of risk factors for the development of OA, including age, gender, genetic predisposition, overweight, injuries, repeated loads, joint deformation and some diseases (rheumatoid arthritis, gout).
  5. Treatment: A review of modern methods of treatment of OA, including drug therapy (analgesics, NSAIDs, corticosteroids, chondroprotectors), physiotherapy, physiotherapy exercises, hyaluronic acid injections and surgical treatment (arthroscopy, endoprosthetics).
2. Rheumatoid arthritis (RA):
  1. Determination and pathogenesis: A detailed description of rheumatoid arthritis as an autoimmune disease that affects the synovial joint of the joints. An explanation of pathogenesis, including the role of autoantiber (rheumatoid factor, anti-central heating), inflammatory cytokines and immune cells. Description of changes in the joints with RA, including synovitis, pannus and destruction of cartilage and bones.
  2. Symptoms: Description of typical symptoms of RA, including symmetrical pain in the joints, stiffness (especially morning), swelling, redness, limitation of movements, fatigue, fever and general symptoms of inflammation. Description of the extra -implemented manifestations of RA (damage to the skin, lungs, heart, eyes).
  3. Diagnosis: A review of the methods of diagnosis of RA, including clinical examination, blood test (rheumatoid factor, anti-central heating, ESR, C-reactive protein), radiography and ultrasound. An explanation of the role of each method in confirmation of the diagnosis and assessment of the activity of the disease. Diagnostic criteria for RA (ACR/EULAR).
  4. Risk factors: Analysis of risk factors for the development of RA, including a genetic predisposition (HLA-DRB1 genes), smoking, infection and hormonal factors.
  5. Treatment: Overview of modern methods of treatment of RA, including basic therapy (methotrexate, sulfasalazine, hydroxychlorokhin, leflunomide), biological therapy (FNO inhibitors, IL-6 inhibitors, inhibitors of costimulations, JAK inhibitors), NSPVP, corticosteroids, physiotherapy and physiotherapy and physiotherapy, and physiotherapy, and physiotherapy, and physiotherapy. Surgical treatment.
3. Gout:
  1. Determination and pathogenesis: A detailed description of gout as a disease caused by the accumulation of uric acid crystals in the joints and other tissues. An explanation of pathogenesis, including violation of uric acid metabolism, hyperuricemia and the formation of tofus (deposits of uric acid crystals).
  2. Symptoms: Description of typical gout symptoms, including acute attacks of joint pain (most often in the thumb of the foot), redness, swelling, inflammation and soreness. Description of chronic gout with the formation of tofus and kidney damage.
  3. Diagnosis: A review of the diagnostics of gout, including the analysis of the synovial fluid (detection of uric acid crystals), blood test (uric acid level), radiography and ultrasound.
  4. Risk factors: Analysis of risk factors for the development of gout, including genetic predisposition, diet, rich in purines (red meat, seafood, alcohol), obesity, metabolic syndrome, kidney disease and taking some drugs (diuretics).
  5. Treatment: A review of modern methods of treatment of gout, including the relief of acute attacks (NSAIDs, Colchicin, corticosteroids), decrease in uric acid levels (allopurinol, phyubuxostat, probenecide) and a diet with restriction of purines.
4. Other joint diseases: A brief description of other common joint diseases, including:
  1. Septic arthritis: Infectious damage to the joint.
  2. Psoriatic arthritis: Arthritis associated with psoriasis.
  3. Anquilizing spondylitis (Bekhtereva’s disease): Inflammatory disease of the spine and large joints.
  4. System red lupus (SLE): Autoimmune disease that affects many organs, including joints.
  5. Bursitis and Tendinitis: Inflammation of the articular bags and tendons.
Factors affecting the health of the joints:
1. Age: An explanation of age -related changes in the joints, including a decrease in the elasticity of the cartilage, a decrease in the amount of synovial fluid and weakening of the ligaments.
2. Weight: Discussion of the influence of overweight on the joints, especially on the knee and hip. Explanation of an increase in the load on the joints and acceleration of the destruction of cartilage.
3. Injuries: Consideration of the role of injuries (fractures, dislocations, stretching) in the development of joint diseases. Explanation of damage to cartilage, ligaments and other articular structures.
4. Physical activity: Discussion of the influence of physical activity on the health of the joints. An explanation of the benefits of moderate physical exertion to strengthen muscles, improve blood supply to joints and maintain cartilage health. Caution of the harm of excessive loads and improper technique of performing exercises.
5. Nutrition: Consideration of the role of nutrition in maintaining joint health. An explanation of the importance of consumption of a sufficient amount of protein, vitamins (D, C, E), minerals (calcium, magnesium, zinc) and omega-3 fatty acids. Discussion of the influence of inflammatory products (sugar, processed products) on the joints.
6. Genetics: An explanation of the role of a genetic predisposition in the development of joint diseases, especially the OA and RA.

Part 2: Dietrs for the joints: Review of components and action mechanisms

Glucosamine:
1. Chemical structure and sources: Description of the chemical structure of glucosamine (aminosahar). Consideration of glucosamine sources (crust -shaped chitin, grain fermentation). An explanation of various forms of glucoseamine (glucoseam sulfate, glucose a hydrochloride, n-acetylhlucosamine) and their bioavailability.
2. The mechanism of action: A detailed description of the mechanism of action of glucosamine, including:
  1. Stimulation of the synthesis of proteoglycans and glycosaminoglycans (GAG) in cartilage.
  2. Inhibition of the activity of enzymes that destroy cartilage (metal proproteinase).
  3. Anti -inflammatory action.
  4. Stimulation of the synthesis of hyaluronic acid in the synovial fluid.
3. Clinical research: A review of clinical studies that evaluate glucosamine with OA. Analysis of research results regarding the reduction of pain, improve the function of joints and slow down the progression of the disease. Discussion of conflicting research results and factors affecting the effectiveness of glucosamine.
4. Indications and contraindications: Listing indications for the use of glucosamine (OA, prevention of joint diseases). Indication of contraindications (individual intolerance, pregnancy, breastfeeding, children’s age).
5. Side effects: Description of possible side effects of glucosamine (digestive disorders, allergic reactions).
6. Interaction with other drugs: Discussion of possible glucosamine interactions with other drugs (anticoagulants).
7. Recommendations for use: Recommendations for the dosage and duration of glucosamine. Discussion of the appropriateness of glucosamine combining with other components (chondroitin, MSM).
Hondroitine Sulfate:
1. Chemical structure and sources: Description of the chemical structure of chondroitin sulfate (GAG). Consideration of sources of chondroitin sulfate (cattle cartilage, shark cartilage). Explanation of various types of chondroitin sulfate (chondroitin sulfate a, chondroitin sulfate c) and their bioavailability.
2. The mechanism of action: A detailed description of the mechanism of action of chondroitin sulfate, including:
  1. Stimulation of the synthesis of proteoglycans and glycosaminoglycans (GAG) in cartilage.
  2. Inhibition of the activity of enzymes that destroy cartilage (metal proproteinase).
  3. Anti -inflammatory action.
  4. Improving the viscosity of synovial fluid.
  5. Stimulation of the synthesis of hyaluronic acid.
3. Clinical research: A review of clinical studies that evaluate the effectiveness of chondroitin sulfate at the OA. Analysis of research results regarding the reduction of pain, improve the function of joints and slow down the progression of the disease. Discussion of conflicting research results and factors affecting the effectiveness of sulfate chondroitin.
4. Indications and contraindications: Listing indications for the use of chondroitin sulfate (OA, prevention of joint diseases). Indication of contraindications (individual intolerance, pregnancy, breastfeeding, children’s age).
5. Side effects: Description of the possible side effects of chondroitin sulfate (digestive disorders, allergic reactions).
6. Interaction with other drugs: Discussion of possible interactions of chondroitin sulfate with other drugs (anticoagulants).
7. Recommendations for use: Recommendations for the dosage and duration of chondroitin sulfate. Discussion of the appropriateness of combining chondroitin sulfate with other components (glucosamine, MSM).
Methyl sulfonylmetatan (MSM):
1. Chemical structure and sources: Description of the chemical structure of MSM (organic compound of sulfur). Consideration of MSM sources (fruits, vegetables, cereals, milk).
2. The mechanism of action: A detailed description of the mechanism of action of MSM, including:
  1. Participation in the synthesis of collagen.
  2. Anti -inflammatory action.
  3. Antioxidant action.
  4. Improving the permeability of cell membranes.
3. Clinical research: A review of clinical studies that evaluate the effectiveness of MSM in OA and other joint diseases. Analysis of research results regarding the reduction of pain, improve the function of joints and reduce inflammation.
4. Indications and contraindications: Listing indications for the use of MSM (OA, arthritis, bursitis, tendonitis, muscle pain). Indication of contraindications (individual intolerance, pregnancy, breastfeeding).
5. Side effects: Description of the possible side effects of MSM (digestive disorders, headache, skin rash).
6. Interaction with other drugs: Discussion of possible interactions of MSM with other drugs.
7. Recommendations for use: Recommendations for the dosage and duration of MSM. Discussion of the appropriateness of combining MSM with other components (glucosamine, chondroitin).
Hyaluronic acid:
1. Chemical structure and sources: Description of the chemical structure of hyaluronic acid (GAG). Consideration of sources of hyaluronic acid (scallopes of roosters, fermentation of bacteria).
2. The mechanism of action: A detailed description of the mechanism of action of hyaluronic acid, including:
  1. Improving the viscosity of synovial fluid.
  2. Lubrication of articular surfaces.
  3. Shock absorption of the load on the joint.
  4. Anti -inflammatory action.
  5. Stimulation of the synthesis of endogenous hyaluronic acid.
3. Clinical research: A review of clinical studies that evaluate the effectiveness of hyaluronic acid in OA (both in the form of oral additives and in the form of intra -articular injections). Analysis of research results regarding the reduction of pain, improve the function of joints and slow down the progression of the disease.
4. Indications and contraindications: Transfer of indications for the use of hyaluronic acid (OA). Indication of contraindications (individual intolerance, infection in the joint).
5. Side effects: Description of the possible side effects of hyaluronic acid (local reactions after injection, digestive disorder during oral administration).
6. Interaction with other drugs: Discussion of possible interactions of hyaluronic acid with other drugs.
7. Recommendations for use: Recommendations for the dosage and method of using hyaluronic acid.
Collagen:
1. Chemical structure and sources: Description of the chemical structure of collagen (protein). Consideration of various types of collagen (type I, type II, type III) and their role in the body. Description of collagen sources (leather, bones, cartilage cartilage, sea fish).
2. The mechanism of action: A detailed description of the mechanism of action of collagen, including:
  1. Providing building material for cartilage, ligaments and tendons.
  2. Stimulation of the synthesis of endogenous collagen.
  3. Improving the elasticity and strength of connective tissue.
3. Clinical research: A review of clinical studies that evaluate the effectiveness of collagen in OA and other joint diseases. Analysis of research results regarding the reduction of pain, improve the function of joints and increase the density of bone tissue.
4. Indications and contraindications: The listing of indications for the use of collagen (OA, osteoporosis, injuries of ligaments and tendons, prevention of skin aging). Indication of contraindications (individual intolerance).
5. Side effects: Description of possible side effects of collagen (digestive disorders, allergic reactions).
6. Interaction with other drugs: Discussion of possible collagen interactions with other drugs.
7. Recommendations for use: Recommendations for the dosage and duration of collagen.
Omega-3 fatty acids:
1. Chemical structure and sources: Description of the chemical structure of omega-3 fatty acids (eicosapentaenoic acid (EPC), non-oxacenoic acid (DHG), alpha-linolenic acid (Alc)). Consideration of sources of omega-3 fatty acids (fatty fish, fish oil, linen seed, walnuts).
2. The mechanism of action: A detailed description of the mechanism of action of omega-3 fatty acids, including:
  1. Anti -inflammatory action (a decrease in the synthesis of pro -inflammatory cytokines).
  2. Improving the blood supply to the joints.
  3. Reducing the risk of cardiovascular diseases.
3. Clinical research: A review of clinical studies that evaluate the effectiveness of omega-3 fatty acids at OA and RA. Analysis of research results regarding the reduction of pain, improve the function of joints and reduce stiffness.
4. Indications and contraindications: The listing of indications for the use of omega-3 fatty acids (OA, RA, cardiovascular diseases, prevention of inflammatory diseases). Indication of contraindications (blood coagulation disorders, individual intolerance).
5. Side effects: Description of the possible side effects of omega-3 fatty acids (digestive disorders, fish flavor, increase in the risk of bleeding).
6. Interaction with other drugs: Discussion of possible interactions of omega-3 fatty acids with other drugs (anticoagulants).
7. Recommendations for use: Recommendations for the dosage and duration of the admission of omega-3 fatty acids.
Vitamin D:
1. Chemical structure and sources: Description of the chemical structure of vitamin D (cholelciferol, ergocalciferol). Consideration of vitamin D sources (sunlight, oily fish, egg yolk, enriched products).
2. The mechanism of action: A detailed description of the mechanism of action of vitamin D, including:
  1. Regulation of calcium and phosphorus metabolism.
  2. Maintaining the health of bones and teeth.
  3. Immunomodulating action.
  4. Anti -inflammatory action.
3. Clinical research: A review of clinical studies that evaluate the effect of vitamin D on joint diseases. Analysis of research results relating to the relationship of vitamin D deficiency with the risk of development of OA and RA.
4. Indications and contraindications: The listing of indications for the use of vitamin D (prevention and treatment of vitamin D deficiency, osteoporosis, rickets). Indication of contraindications (hypercalcemia, hypervitaminosis D).
5. Side effects: Description of the possible side effects of vitamin D (hypercalcemia, nausea, vomiting, weakness).
6. Interaction with other drugs: Discussion of possible interactions of vitamin D with other drugs (diuretics, heart glycosides).
7. Recommendations for use: Recommendations for the dosage and method of using vitamin D.
Curcumin:
1. Chemical structure and sources: Description of the chemical structure of curcumin (polyphenol). Consideration of the sources of turskumin (turmeric).
2. The mechanism of action: A detailed description of the mechanism of action of curcumin, including:
  1. Anti-inflammatory action (inhibiting NF-κB, cyclooxygenase-2 (COO-2) and other inflammatory mediators).
  2. Antioxidant action.
  3. Analgesic effect.
3. Clinical research: A review of clinical studies that evaluate the effectiveness of turcumin in OA and other joint diseases. Analysis of research results regarding the reduction of pain, improve the function of joints and reduce inflammation. Discussion of problems with the bioavailability of curcumin and ways to increase it (for example, with a piperin).
4. Indications and contraindications: Transfer of indications for the use of curcumin (OA, arthritis, inflammatory diseases, cancer prevention). Indication of contraindications (individual intolerance, pregnancy, breastfeeding, gall bladder disease).
5. Side effects: Description of the possible side effects of curcumin (digestive disorders, allergic reactions).
6. Interaction with other drugs: Discussion of possible interactions of curcumin with other drugs (anticoagulants).
7. Recommendations for use: Recommendations for the dosage and method of using curcumin.
Boswellia serrata Boswellia):
1. Composition and sources: Description of the composition of the Boswellion of Pilchate (Boswellic acids). Consideration of sources (resin of wood Boswellia Serrata).
2. The mechanism of action: A detailed description of the mechanism of action of the Boswellion of Pilchate, including:
  1. Anti-inflammatory effect (inhibiting 5-lipoxygenases (5-log)).
  2. Analgesic effect.
  3. Chondroprotector action.
3. Clinical research: An overview of clinical studies that evaluate the effectiveness of the pile bosvellia in OA and other joint diseases. Analysis of research results regarding the reduction of pain, improve the function of joints and reduce inflammation.
4. Indications and contraindications: The listing of indications for the use of Boswelliya Pilchate (OA, arthritis, bronchial asthma). Indication of contraindications (individual intolerance, pregnancy, breastfeeding).
5. Side effects: Description of the possible side effects of the Boswelliy of Pilchate (digestive disorders, allergic reactions).
6. Interaction with other drugs: Discussion of the possible interactions of the Boswelliy Pilchate with other drugs.
7. Recommendations for use: Recommendations for the dosage and the method of applying the Boswelliy Pilchate.

Part 3: The opinions of doctors about dietary supplements for joints

The general attitude of doctors to dietary supplements:
1. Disagreements in the medical community: Description of disagreements in the opinions of doctors regarding the effectiveness and safety of dietary supplements. Discussion of factors affecting the attitude of doctors to dietary supplements (level of evidence, product quality, marketing, personal experience).
2. Bades evaluating criteria: A description of the criteria that doctors use to evaluate dietary supplements (the presence of clinical research, safety, quality of production, compliance with the declared composition).
3. Information of patients: Discussion of the importance of informing patients about dietary supplements, their potential benefits and risks, as well as the need to consult a doctor before starting.
The opinions of doctors about glucosamine and chondroitin:
1. Efficiency in osteoarthritis: Analysis of the opinions of doctors regarding the effectiveness of glucosamine and chondroitin at OA. Discussion of research confirming and refuting their effectiveness.
2. The role in slowing the progression of the disease: Assessing by doctors the role of glucosamine and chondroitin in a slowdown in the progression of OA.
3. Safety and side effects: Discussion of the safety of glucosamine and chondroitin and their possible side effects.
4. Doctors’ recommendations: Description of the recommendations of doctors regarding the use of glucosamine and chondroitin with OA (dosage, duration of administration, combination with other treatment methods).
5. Alternative opinions: The presentation of alternative opinions of doctors who are skeptical of the use of glucosamine and chondroitin.
The opinions of doctors about MSM:
1. Anesthetic and anti -inflammatory action: Analysis of the opinions of doctors relative to the analgesic and anti -inflammatory effects of MSM.
2. Clinical research: Discussion of clinical studies that evaluate the effectiveness of MSM in joint diseases.
3. Safety and side effects: Discussion of the safety of MSM and its possible side effects.
4. Doctors’ recommendations: Description of the recommendations of doctors regarding the use of MSM for joint diseases (dosage, duration of administration, combination with other treatment methods).
The opinions of doctors about hyaluronic acid:
1. Intra -articular injections: Discussion of the effectiveness and safety of intra -articular injections of hyaluronic acid in OA.
2. October reception: Assessment by doctors of the effectiveness of oral administration of hyaluronic acid in OA.
3. Doctors’ recommendations: Description of the recommendations of doctors regarding the use of hyaluronic acid in OA (method of use, dosage, duration of treatment).
The opinions of doctors about collagen:
1. Building material for the joints: Discussion of the role of collagen as a building material for cartilage, ligaments and tendons.
2. Clinical research: A review of clinical studies that evaluate the effectiveness of collagen in joint diseases.
3. Safety and side effects: Discussion of collagen safety and its possible side effects.
4. Doctors’ recommendations: Description of the recommendations of doctors regarding the use of collagen for joint diseases (type of collagen, dosage, duration of administration).
The opinions of doctors about omega-3 fatty acids:
1. Anti -inflammatory action: Discussion of the anti-inflammatory effect of omega-3 fatty acids and their role in the treatment of joint diseases.
2. Clinical research: A review of clinical studies that evaluate the effectiveness of omega-3 fatty acids at OA and RA.
3. Safety and side effects: Discussion of the safety of Omega-3 fatty acids and their possible side effects.
4. Doctors’ recommendations: Description of the recommendations of doctors regarding the use of omega-3 fatty acids for joint diseases (dosage, source of omega-3 fatty acids).
The opinions of doctors about vitamin D:
1. The role in maintaining bone health: Discussion of the role of vitamin D in maintaining bone health and prevention of osteoporosis.
2. Communication with joint diseases: Review of studies that evaluate the relationship of vitamin D deficiency with the risk of developing OA and RA.
3. Doctors’ recommendations: Description of the recommendations of doctors regarding the use of vitamin D for the prevention and treatment of joint diseases (dosage, method of use).
The opinions of doctors about Kurkumin and Pilchatny Boswelli:
1. Anti -inflammatory action: Discussion of the anti -inflammatory effect of Kurkumin and Boswelliya Pilchaty and their role in the treatment of joint diseases.
2. Clinical research: An overview of clinical studies that evaluate the effectiveness of turcuminal and pile bosvellia in OA and other joint diseases.
3. Safety and side effects: Discussion of the safety of Kurkumin and Boswellion of Pilchate and their possible side effects.
4. Doctors’ recommendations: Description of the recommendations of doctors regarding the use of Kurkumin and Pilchate Boswellion for joint diseases (dosage, method of use, combination with other treatment methods).

Part 4: How to choose a dietary supplement for joints: recommendations and warnings

Bad selection criteria:
1. Composition: Analysis of the composition of the dietary supplement and its compliance with the declared ingredients.
2. Dosage: Assessment of the dosage of ingredients and its compliance with the recommended doses.
3. Output form: The choice of the optimal form of dietary supplement release (tablets, capsules, powder, liquid).
4. Manufacturer: The choice of a reliable manufacturer with a good reputation.
5. Certification: The presence of quality and compliance certificates with standards.
6. Reviews: Analysis of consumer reviews and doctors.
7. Price: Assessment of the ratio of price and quality of dietary supplements.
Cautions:
1. Does not replace the main treatment: The emphasizing that dietary supplements are not a replacement for the main treatment of joint diseases.
2. Possible side effects: A warning about possible side effects and the need to consult a doctor.
3. Interaction with drugs: Caution on the possible interaction of dietary supplements with other drugs.
4. Insufficient evidence base: Informing about evidence deficiency

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