Complex of dietary supplements for the health of prostate: deep immersion in science, compositions and effectiveness
Chapter 1: Anatomy and Physiology of Prostate: The foundation for understanding
Before delving into the world of biologically active additives (dietary supplements) for the health of the prostate, it is necessary to have a clear idea of the prostate gland itself, its functions and potential problems that may arise.
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Location and structure: The prostate is a small gland the size of a walnut, located directly under the bladder in men and the surrounding part of the urethra (urethra). It is part of the male reproductive system. Anatomically, the prostate is divided into several zones: peripheral, central, transitional and front fibromoscular stroma. The peripheral zone is most susceptible to the development of prostate cancer, while benign prostate hyperplasia (DGPZ) often begins in the transition zone.
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Prostate functions: The main function of the prostate is the production of liquid, which is a significant part of the sperm. This prostatic fluid contains various substances, including enzymes (for example, prostatetsceptic antigen — PSA), zinc and citric acid, which contribute to the survival and mobility of sperm. The prostate also plays a role in the control of urination, since its size and location can affect the stream of urine.
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Age -related changes in the prostate: With age, the prostate naturally increases in size, which is a normal physiological process. However, an excessive increase can lead to compression of the urethra and the development of symptoms of DHCH. Hormonal changes, especially a decrease in testosterone levels and an increase in the level of digidrotestosterone (DGT), play a key role in this process.
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Common diseases of the prostate: There are three main diseases of the prostate:
- Benign prostate hyperplasia (DGPZH): This is a nonsense increase in the prostate, which can lead to urination problems, such as frequent urge, a weak urine stream and night urination (nicturia).
- Prostatitis: This is an inflammation of the prostate, which can be caused by a bacterial infection or other factors. Symptoms can vary from slight discomfort to severe pain, fever and urination problems. There are various types of prostatitis, including acute bacterial prostatitis, chronic bacterial prostatitis, chronic abacterial prostatitis/chronic pelvic pain and asymptomatic inflammatory prostatitis.
- Prostate cancer: This is a malignant tumor that develops in the prostate. Prostate cancer often develops slowly and may not cause any symptoms in the early stages. Regular screening, such as determining the level of PSA and a finger rectal study, are important for early detection.
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Risk factors for prostate diseases: Some factors can increase the risk of prostate diseases, including:
- Age: The risk of gearbox and prostate cancer increases with age.
- Family history: The presence of relatives suffering from prostate diseases can increase the risk.
- Race/ethnicity: The African Americans have a higher risk of prostate cancer than representatives of other races.
- Diet: A high content of saturated fats and a low content of fruits and vegetables can increase risk.
- Obesity: Obesity is associated with an increased risk of developing DGPZ and prostate cancer.
Chapter 2: Dietary Bades for Prostate health: Overview of key ingredients
The dietary supplement market for the health of the prostate is huge and diverse, offering many products containing various ingredients. In this section, we will consider in detail the most common and studied ingredients, as well as consider scientific evidence confirming their effectiveness.
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SAW Palmetto palm extract:
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The mechanism of action: Serenoa Palma extract (Serenoa Repens) is perhaps the most famous and studied dietary supplement for the treatment of symptoms of DHCH. It is believed that it acts in several ways, including:
- Inhibiting 5-alpha reductase: This enzyme turns testosterone into DGT, which plays a key role in prostate growth. Inhibition of 5-alpha reductase can help reduce the size of the prostate and relieve symptoms of DHCH.
- Antiandrogenic effects: Cerehena palm extract can block the binding of DGT with androgens receptors in prostate cells, which can also slow down the growth of the prostate.
- Anti -inflammatory effect: inflammation can also contribute to the development of DHCH, and the Extract of the Palma of Serenia has anti -inflammatory properties.
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Scientific evidence: There are many clinical studies that evaluate the effectiveness of the Extract of the Serenia palm with DHCH. Some studies have shown that it can reduce the symptoms of DHCH, such as frequent urination, night urination and a weak stream of urine. However, the research results vary, and some studies have not shown a significant improvement compared to placebo. It is important to note that the effectiveness of the extract of the palm palm can depend on the dose, the quality of the extract and the individual characteristics of the patient. The meta-analyzes and systematic reviews showed the moderate effectiveness of the Extract of the Serene palm in improving the symptoms of the lower urinary tract associated with the DGPS.
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Recommended dosage: Usually the recommended dose of the serenia palm extract is 320 mg per day. It is important to choose an extract standardized for the content of fatty acids (usually 85-95%).
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Side effects: Serene palm extract is usually well tolerated, but in some cases side effects can occur, such as stomach disorders, nausea and headache. Cases of sexual dysfunction were rarely reported.
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Beta Sitosterin:
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The mechanism of action: Beta -Sitosterin is a phytosterol (plant sterol), which is contained in many plants, including Sereena palm. It is believed that it acts by reducing inflammation in the prostate and improving urine flow. The exact mechanism of the action of beta-sytosterin at the DHGPZH is not fully studied, but it is assumed that it can affect the metabolism of cholesterol in prostate cells and modulate the immune system.
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Scientific evidence: Some studies have shown that beta-sytosterin can improve the symptoms of DHCH, such as frequent urination, night urination and a weak stream of urine. The meta-analysis showed that beta-sytosterin can significantly improve urodynamic parameters, such as the maximum urine flow rate and the residual volume of urine after urination.
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Recommended dosage: Usually the recommended dose of beta-sytosterine is from 60 to 130 mg per day.
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Side effects: Beta-Sitosterin is usually well tolerated, but in some cases side effects can occur, such as stomach disorders.
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Floral pollen of rye (Cernilton):
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The mechanism of action: RZH flower pollen extract is a standardized extract of rye pollen, which is used to treat symptoms of DHCS and prostatitis. It is believed that it has anti -inflammatory, anti -angogenic and antiperibratic properties. It is assumed that Cernilton suppresses the growth of prostate cells, reduces inflammation and improves the tone of the muscles of the bladder.
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Scientific evidence: Some studies have shown that rye flower pollen extract can improve the symptoms of DGPZ and prostatitis, such as pain, discomfort and urination problems. However, additional studies are needed to confirm these results. Some studies have shown that Cernilton can be effective in the treatment of chronic prostatitis/chronic pelvic pain syndrome.
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Recommended dosage: The dosage of the extract of flower pollen of rye can vary depending on the product, but usually ranges from 60 to 126 mg per day.
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Side effects: Floral pollen extract of rye is usually well tolerated, but in some cases side effects can occur, such as stomach disorders and allergic reactions (especially in people with allergies to pollen).
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African pidgeum (Pygeum Africanum):
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The mechanism of action: African cortex extract of the pidgeum (Pygeum Africanum) is used to treat the symptoms of DHCH. It is believed that it acts by reducing inflammation in the prostate and improving urine flow. Pidgeum contains phytosterols, triterpenes and other compounds that can have anti -inflammatory and antioxidant effects. It is assumed that Pidgeum can also inhibit the growth of prostate cells.
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Scientific evidence: Some studies have shown that African piddle extract can improve the symptoms of DHCH, such as frequent urination, night urination and a weak urine stream. The meta-analyzes have shown that pidgeum can significantly improve the symptoms of the lower urinary tract associated with DHCH.
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Recommended dosage: The usually recommended dose of African pidge extract is from 50 to 200 mg per day.
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Side effects: African pidget extract is usually well tolerated, but in some cases side effects can occur, such as stomach disorders.
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Liquopin:
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The mechanism of action: Lycopine is a carotenoid pigment contained in tomatoes and other red fruits and vegetables. It has powerful antioxidant properties and can protect prostate cells from damage caused by free radicals. Studies show that lycopine can reduce the risk of prostate cancer.
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Scientific evidence: Some studies have shown that lycopine can reduce the risk of prostate cancer and slow down its progression. It can also improve the health of prostate in men with DGPG. However, additional studies are needed to confirm these results. The mechanism of action of lycopine in the prevention of prostate cancer includes antioxidant protection, inhibiting cell growth and stimulation of apoptosis (programmed cell death).
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Recommended dosage: Usually the recommended dose of lycopine is from 10 to 30 mg per day.
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Side effects: Lycopine is usually well tolerated, but in some cases it can cause stomach disorders or a change in skin color (lycopinemia).
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Selenium:
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The mechanism of action: Selenium is a mineral that plays an important role in antioxidant protection and immune function. It can also protect prostate cells from damage caused by free radicals. Studies show that selenium can reduce the risk of prostate cancer.
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Scientific evidence: Some studies have shown that selenium can reduce the risk of prostate cancer. However, the results of the studies vary, and additional studies are needed to confirm these results. Selenium can act synergically with other antioxidants such as E. Vitamin
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Recommended dosage: The recommended daily dose of selenium is 55 μg. The recommended dose should not exceed, since the excess selenium can be toxic.
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Side effects: Selenium is usually well tolerated, but in high doses can cause side effects, such as stomach disorders, hair loss and damage to the nervous system.
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Zinc:
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The mechanism of action: Zinc is a mineral that plays an important role in immune function, reproductive function and prostate health. It is contained in high concentrations in the prostate and can protect the prostate cells from damage. Zinc can also inhibit the growth of prostate cells.
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Scientific evidence: Studies show that zinc can reduce the risk of prostate cancer and improve the symptoms of DHCH. Zinc deficiency may be associated with an increased risk of prostate diseases.
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Recommended dosage: The recommended daily dose of zinc is 11 mg for men.
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Side effects: Zinc is usually well tolerated, but in high doses can cause side effects, such as stomach disorders, nausea and vomiting. Long -term intake of high doses of zinc can lead to copper deficiency.
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Vitamin D:
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The mechanism of action: Vitamin D plays an important role in bone health, immune function and cellular regulation. Studies show that vitamin D deficiency can be associated with an increased risk of prostate cancer. Vitamin D can inhibit the growth of prostate cells and stimulate their differentiation.
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Scientific evidence: Some studies have shown that vitamin D can reduce the risk of prostate cancer and slow down its progression. However, the results of the studies vary, and additional studies are needed to confirm these results.
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Recommended dosage: The recommended daily dose of vitamin D is 600 IU (international units). Many people need higher doses, especially those who live in northern latitudes or have dark skin. It is recommended to take a blood test for vitamin D to determine the optimal dose.
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Side effects: Vitamin D is usually well tolerated, but in high doses can cause side effects, such as hypercalcemia (increased blood calcium), nausea, vomiting and weakness.
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Quercetin:
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The mechanism of action: Quercetin is a flavonoid contained in many fruits and vegetables, such as onions, apples and berries. It has powerful antioxidant and anti -inflammatory properties. Studies show that quercetin can reduce the risk of prostate cancer and improve prostatitis symptoms.
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Scientific evidence: Some studies have shown that quercetin can reduce the risk of prostate cancer and improve the symptoms of chronic prostatitis/chronic pelvic pain syndrome. It can reduce inflammation, pain and discomfort associated with prostatitis.
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Recommended dosage: The dosage of quercetine can vary, but usually ranges from 500 to 1000 mg per day. It is recommended to take quercetin with food to improve its absorption.
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Side effects: Quercetin is usually well tolerated, but in some cases it can cause stomach disorders or headache.
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Chapter 3: Scientific research and clinical tests of dietary supplements for prostate
In the previous chapter, we examined separate ingredients of dietary supplements for the health of the prostate. Now it is important to consider the results of scientific research and clinical trials that evaluate the effectiveness of these dietary supplements as a whole and in combination with each other.
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Meta-analyzes and systematic reviews: Met-analyzes and systematic reviews combine the results of several studies to obtain more reliable conclusions. Some meta-analyzes have shown that the Extract of the Palma of Serenoa, Beta Sitosterin and African Pidgeum can improve the symptoms of DGPG. However, it is important to note that the quality of studies included in these meta-analyzes can vary, which can affect the results.
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Randomized controlled studies (RCTs): RCTs are the gold standard of scientific research. In RCTs, participants are randomly distributed into groups receiving either dietary supplements or a placebo (fictitious treatment). Then the results between the groups are compared. There are many RCTs that evaluate the effectiveness of various dietary supplements for the health of the prostate. Some RCTs showed positive results, while others did not show a significant improvement compared to placebo. It is important to carefully evaluate the methodology and results of each RCT before drawing conclusions about the effectiveness of the dietary supplement.
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Research of batdles: Many dietary supplements for prostate health contain combinations of various ingredients. Some studies have shown that dietary supplements can be more effective than individual ingredients. For example, a combination of the extract of palm trees, beta-sytosterin and lycopene can be more effective in improving the symptoms of DGPZH than each ingredient separately. However, additional studies are needed to determine the optimal combinations of dietary supplements and their dosages.
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Critical remarks regarding the research of dietary supplements: It is important to note that research studies often face a number of problems, including:
- Small sizes of sample: Many studies of dietary supplements are small in sample size, which can limit their statistical power.
- The heterogeneity of the participants: Research participants can be heterogeneous by age, severity of symptoms and other factors, which can complicate the interpretation of the results.
- Varying quality of dietary supplements: The quality of dietary supplements can vary depending on the manufacturer, which can affect the results of the research.
- Lack of long -term research: Many dietary supplements are short -term, therefore it is difficult to assess their long -term efficiency and safety.
- Research financing: Some studies of dietary supplements can be financed by dietary supplements, which can lead to biased results.
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The need for further research: Despite the available studies, additional studies are needed to confirm the effectiveness and safety of dietary supplements for the health of the prostate. Future research should be larger, well planned and long -term. It is also necessary more studies that evaluate the combinations of dietary supplements and their impact on various aspects of the health of the prostate, such as the risk of prostate cancer, the progression of DGPZ and the symptoms of prostatitis.
Chapter 4: An individual approach to choosing dietary supplements for prostate health
The choice of dietary supplement for the health of the prostate is an individual process that should take into account many factors, including:
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Symptoms: It is important to determine what symptoms you want to relieve. For example, if you have symptoms of DHPH, such as frequent urination and a weak urine stream, you may suit a dietary supplement containing the Extract of the Palma of Serenoa or Beta Sitosterin. If you have symptoms of prostatitis, you may suit a dietary supplement containing a flower pollen extract of rye or quercetin.
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Health status: It is important to consider the state of your health, including any chronic diseases and medications taken. Some dietary supplements can interact with medicines or be contraindicated in certain diseases.
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Allergies: It is important to consider any allergies that you have. Some dietary supplements contain ingredients that can cause allergic reactions.
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Age: It is important to consider your age. Some dietary supplements can be more suitable for certain age groups.
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Preferences: It is important to consider your preferences. Some people prefer natural dietary supplements, while others prefer more traditional medicines.
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Consultation with a doctor: It is extremely important to consult a doctor before starting to take any dietary supplement for the health of the prostate. The doctor can evaluate your health status, determine the cause of your symptoms and recommend the most suitable dietary supplement or a combination of dietary supplements. The doctor can also help you track any side effects or drug interactions.
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Choosing a quality product: It is important to choose a quality product from a reliable manufacturer. Look for products that were tested by the third side for cleanliness and potency. Read the reviews of other users to find out about their experience with the product.
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Dosage: It is important to observe the recommended dosage indicated on the product label. Do not take any more recommended dose, as this can increase the risk of side effects.
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Expectations: It is important to have realistic expectations with respect to the results of dietary supplements. Bades can help alleviate the symptoms of prostate diseases, but they are not a medicine. It may take several weeks or months to see the results of dietary supplement.
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Monitoring: It is important to monitor your symptoms and side effects during a dietary supplement. If you have any side effects, stop taking dietary supplements and consult a doctor.
Chapter 5: The role of diet and lifestyle in prostate health
In addition to taking dietary supplements, diet and lifestyle play an important role in maintaining the health of the prostate.
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Diet:
- Fruits and vegetables: The use of a large number of fruits and vegetables, especially red and orange, such as tomatoes, watermelons and pumpkin, can reduce the risk of prostate cancer. These fruits and vegetables are rich in lycopine, a powerful antioxidant.
- Green tea: Green tea contains polyphenols that have antioxidant and anti -inflammatory properties. Some studies have shown that green tea can reduce the risk of prostate cancer.
- Fish: Fat fish, such as salmon, tuna and mackerel, is rich in omega-3 fatty acids. Omega-3 fatty acids have anti-inflammatory properties and can reduce the risk of prostate diseases.
- Healthy fats: The use of healthy fats, such as olive oil, avocados and nuts, can reduce the risk of prostate diseases.
- Limiting red meat and dairy products: The use of a large amount of red meat and dairy products with a high fat content can increase the risk of prostate cancer.
- Limiting sugar and processed products: The use of a large amount of sugar and processed products can contribute to inflammation and an increase in the risk of developing prostate diseases.
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Life:
- Regular physical exercises: Regular physical exercises can help reduce the risk of developing prostate diseases and improve the general health.
- Maintaining a healthy weight: Obesity is associated with an increased risk of developing prostate diseases. Maintaining a healthy weight can reduce this risk.
- Refusal of smoking: Smoking is associated with an increased risk of prostate cancer. Refusal of smoking can reduce this risk.
- Stress management: Chronic stress can contribute to inflammation and an increase in the risk of developing prostate diseases. Stress management using methods such as yoga, meditation or tai-chi can help reduce this risk.
- Regular prostate examinations: Regular prostate examinations, such as determining the level of PSA and a finger rectal study, are important for the early detection of prostate cancer. Recommendations for examinations of prostate vary, so it is important to discuss them with your doctor.
Chapter 6: Safety and potential side effects of dietary supplements for prostate
Like any other additives or medicines, prostate dietary supplements can have side effects. It is important to know about potential risks and take precautions in order to minimize them.
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General side effects: Many dietary supplements for prostate are well tolerated, but still can cause side effects, such as:
- Stomach disorders
- Nausea
- Diarrhea
- Headache
- Dizziness
These side effects are usually light and pass on their own. If they become serious or do not pass, you should stop taking the additive and consult a doctor.
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Serious side effects: Although this rarely happens, some dietary supplements for prostate can cause serious side effects, such as:
- Allergic reactions (rash, itching, edema, difficulty breathing)
- Interactions with drugs
- Problems with the liver
- Problems with the kidneys
- Increased risk of bleeding
If you have any of these serious side effects, immediately seek medical help.
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Interactions with drugs: Daddles for prostate can interact with the medicines that you take. It is important to inform your doctor about all dietary supplements and medicines that you take to avoid potential interactions. Some examples of potential interactions:
- Serene palm extract can interact with anticoagulants (blood liners), increasing the risk of bleeding.
- Vitamin E can interact with anticoagulants and antiplatelet agents, also increasing the risk of bleeding.
- Quercetin can interact with some antibiotics and chemotherapeutic drugs.
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Precautions: To minimize the risk of side effects, the following precautions should be observed:
- Consult a doctor before taking any dietary supplement for prostate.
- Choose quality products from reliable manufacturers.
- Follow the recommended dosage.
- Stop taking the additive if you have any side effects.
- Tell your doctor about all dietary supplements and medicines that you take.
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The importance of quality control: Since dietary supplements are not regulated as strictly as medicines, it is important to choose products from manufacturers who adhere to strict quality control standards. Look for products that were tested by the third side for cleanliness and potency.
Chapter 7: Dietary supplements for the prevention of prostate cancer: modern prospects
Although no dietary supplement can guarantee the prevention of prostate cancer, some studies show that certain additives can reduce the risk of its development.
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Liquopin: As already mentioned, lycopines contained in tomatoes and other red fruits and vegetables have powerful antioxidant properties and can protect prostate cells from damage that can lead to cancer.
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Selenium: Selenium, an important trace element, also plays a role in antioxidant protection and immune function. Some studies have shown that a higher level of selenium in the blood can be associated with a lower risk of prostate cancer.
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Vitamin D: Vitamin D is important for many aspects of health, including immune function and cell growth. Some studies have shown that vitamin D deficiency may be associated with an increased risk of prostate cancer, although additional studies are needed to confirm this.
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Green tea: Green tea is rich in polyphenols that have antioxidant and anti -inflammatory properties. Some studies have shown that the use of green tea can reduce the risk of prostate cancer.
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Food in general: It is important to note that the best strategy for the prevention of prostate cancer is to adhere to a healthy diet rich in fruits, vegetables, whole grain products and low -fat proteins. Avoid the use of a large amount of red meat, processed products and sugar.
Chapter 8: Bades and treatment of prostatitis: inflammation management and symptoms
Prostatitis is an inflammation of the prostate, which can be caused by a bacterial infection or other factors. Bades can help alleviate the symptoms of prostatitis, such as pain, discomfort and urination problems.
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Quercetin: Quercetin, flavonoid, contained in many fruits and vegetables, has powerful antioxidant and anti -inflammatory properties. Some studies have shown that quercetin can improve the symptoms of chronic prostatitis/chronic pelvic pain syndrome.
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Floral pollen extract of rye (Cernilton): Cernilton, a standardized pyver extract of rye, is traditionally used to treat prostatitis symptoms. It can have anti -inflammatory, antiandrogenic and anti -caulifritive properties.
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Other anti -inflammatory additives: Other supplements with anti -inflammatory properties, such as curcumin (from turmeric) and ginger, can also help alleviate the symptoms of prostatitis.
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Probiotics: Probiotics are useful bacteria that can help improve intestinal health and reduce inflammation throughout the body. Some studies have shown that probiotics can help alleviate the symptoms of prostatitis.
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The importance of an integrated approach: It is important to note that dietary supplements should be used as an addition to the traditional treatment of prostatitis, which may include antibiotics, alpha blockers and painkillers.
Chapter 9: Bades after surgery on the prostate: Support for recovery
After surgery on the prostate, such as radical prostatectomy with prostate cancer or transurethral prostate resection (turp) with DHC, dietary supplements can help maintain recovery and facilitate side effects.
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Vitamin C and vitamin E: These vitamins are powerful antioxidants that can help protect the cells from damage and promote tissue healing after surgery.
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Zinc: Zinc is important for immune function and wound healing. A sufficient amount of zinc can help accelerate recovery after surgery.
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Probiotics: After surgery on the prostate, antibiotics are often prescribed, which can disrupt the balance of bacteria in the intestines. Probiotics can help restore the healthy intestinal balance and reduce the risk of diarrhea associated with antibiotics.
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Amino acids: Amino acids, such as L-Arginine and L-Carnitin, can help improve blood flow and reduce fatigue after surgery.
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Before taking any additives after surgery, consult your surgeon or doctor to make sure that they are safe and do not interact with any medicines that you take.
Chapter 10: New directions in the research of dietary supplements for prostate health
Studies of dietary supplements for the health of prostate are constantly developing. Here are some new directions that should be noted:
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Prostate microbiota: New studies show that the prostate has its own unique microbiota (a set of microorganisms). Violations in the microbiote of the prostate can be associated with prostate diseases, such as prostatitis and prostate cancer. In the future, dietary supplements aimed at modulating microbiots of prostate can be a new approach to the prevention and treatment of prostate diseases.
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Exosome: Exosomas are small bubbles secreted by cells that contain genetic material and other molecules. Exosomas can play a role in communication between cells and the development of prostate diseases. Exosive studies can lead to the development of new dietary supplements aimed at certain signaling paths in