Arginine: To improve blood circulation and nutrition of muscles

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Arginine: To improve blood circulation and nutrition of muscles

I. Arginin: fundamental review

Arginine, or L-Arginine, is a seminocy acid, which plays a critical role in numerous physiological processes. The “semi -replaceable” means that the body can synthesize arginine, but in some situations, such as intense physical activity, illness or growth periods, its own production may be insufficient, requiring food or additives.

A. Chemical structure and properties

Arginine is an alpha amino acid with a side chain containing a guanidine group. This guanidine group gives Arginine alkaline properties and allows it to participate in various biochemical reactions, including the formation of nitrogen oxide (No). Arginine molecular formula: C6H14N4O2. Molar mass: 174.2 g/mol. Arginine is well soluble in water.

B. Sources of Arginina

Arginine enters the body from various sources:

  1. Food sources: Arginine is contained in a large number of food, especially in foods with a high protein content:

    • Meat (beef, pork, chicken, turkey)
    • Fish and seafood (salmon, tuna, shrimp)
    • Eggs
    • Dairy products (cottage cheese, milk, yogurt)
    • Nuts and seeds (peanuts, almonds, walnuts, pumpkin seeds, sunflower seeds)
    • Legumes (soy, beans, lentils)
    • Grain (brown rice, oats)
    • Chocolate (dark chocolate)

  2. Endogenous synthesis: Arginine is synthesized in the body of citrullin, amino acids formed in the urea cycle. This process occurs mainly in the kidneys.

  3. Food additives: Arginine is available in the form of various food additives, including L-Arginin, Arginine Alfa-Ketoglutarate (AAKG) and Arginine hydrochloride. These additives are often used by athletes and people seeking to improve blood circulation and muscle performance.

C. Metabolism Arginina

Arginine metabolism is complicated and includes several important ways:

  1. Nitrogen oxide synthesis (no): Arginine is a direct predecessor of nitrogen oxide (No), powerful vasodilator. The No-syntase enzyme (NOS) catalyzes the transformation of arginine into no and citrullin. No plays a key role in the regulation of blood flow, blood pressure and immune function.

  2. Urea cycle: Arginine is involved in the urea cycle, a process that removes toxic ammonia from the body. Arginine is broken down by the enzyme arginase into ornitin and urea. Urea is excreted from the body through the kidneys.

  3. Synthesis Creatine: Arginine is one of the three amino acids necessary for the synthesis of creatine (the other two are glycine and methionine). Creatine plays an important role in energy metabolism in the muscles.

  4. Synthesis poliamineov: Arginine is the predecessor of polyamins (Putresecin, spermidine and sperm), which are necessary for the growth and differentiation of cells, as well as for the stability of DNA and RNA.

  5. Synthesis Prolina and Glutama: Arginine can be transformed into Prain and glutamate, important amino acids involved in various metabolic processes.

II. Arginin and Blooding

Arginine has a significant effect on blood circulation, mainly due to its role in the synthesis of nitrogen oxide (NO).

A. The role of nitrogen oxide (no)

Nitrogen oxide (No) is a powerful vasodilator, that is, it relaxes the smooth muscles of the walls of blood vessels, which leads to expanding blood vessels and improving blood flow. NO also plays a role in preventing platelet aggregation (blood clots) and a decrease in inflammation in the vessels.

B. Vasodilation mechanisms

No causes vasodilation by activating the enzyme guanilatziclase in the smooth muscle cells of blood vessels. Guanilatziclase increases the production of cyclic guanosine monophosphate (CGMFs), which causes relaxation of smooth muscles and vascular expansion.

C. The influence of Arginine on blood pressure

Several studies have shown that arginine additives can reduce blood pressure in people with hypertension (high blood pressure). This effect is probably associated with an increase in NO production and improvement in vasodilation. However, it is important to note that Arginine is not always effective for reducing blood pressure in people with normal blood pressure.

D. Arginine and Heart-So-Sudit Losses

Improving blood circulation caused by arginine can be useful for people with cardiovascular diseases, such as:

  1. Ichemic heart disease: Improving blood flow in the coronary arteries can reduce the symptoms of angina pectoris (chest pain).

  2. Heart failure: Arginine can improve the function of the endothelium (internal lining of blood vessels) and reduce blood pressure, which can be useful for people with heart failure.

  3. Peripheral arterial disease: Arginine can improve blood flow in the legs, which can reduce pain when walking (intermittent chroma).

  4. Erectile dysfunction: No plays an important role in an erection, and Arginine can improve the erectile function in some men, especially in those who have erectile dysfunction associated with impaired blood flow.

E. Studies on the effect of arginine on blood circulation

Numerous studies studied the influence of Arginine on blood circulation. For example:

  • The meta-analysis of studies showed that arginine additives can reduce systolic and diastolic blood pressure.
  • Studies have shown that Arginine can improve the function of endothelium in people with cardiovascular diseases.
  • Studies have shown that Arginine can improve blood flow in the legs of people with peripheral arterial disease.

III. Arginine and muscle nutrition

Arginine plays an important role in muscle nutrition, both directly and indirectly, through improving blood circulation and the effect on hormonal background.

A. Improving blood flow to the muscles

As described above, Arginine improves blood circulation due to an increase in NO production. Improved blood flow to the muscles provides a greater intake of oxygen, nutrients (such as amino acids, glucose and fatty acids) and hormones necessary for the growth, restoration and functioning of muscles.

B. Influence of Synthesis Belka

Arginine can stimulate the synthesis of protein in the muscles, which is a key process for muscle growth and restoration. The mechanisms through which Arginine affects the synthesis of protein, includes:

  1. Improvement of amino acid transport: Improved blood flow provides more effective delivery of amino acids to muscle cells, which creates favorable conditions for protein synthesis.

  2. Hormonal response stimulation: Arginine can stimulate the release of hormones, such as growth hormone (GR) and insulin, which play an important role in the synthesis of protein.

  3. mTOR (mammalian target of rapamycin): Arginine can activate the MTOR signal path, which is a key regulator of protein synthesis in cells.

C. Impact on growth hormone (gr)

Studies have shown that Arginine can stimulate the release of growth hormone (GR). Gr is a hormone that plays an important role in growth, restoration and metabolism. GR contributes to the synthesis of protein, burning fat and an increase in muscle mass.

D. Impact of Insulin

Arginine can stimulate the release of insulin. Insulin is a hormone that plays an important role in the metabolism of glucose and amino acids. Insulin contributes to the absorption of glucose and amino acids with muscle cells, which contributes to the synthesis of protein and the restoration of glycogen.

E. Reducing muscle fatigue

Improved blood flow and nutrition of muscles provided by arginine can help reduce muscle fatigue during training. This can lead to an increase in endurance and improving sports results.

F. The role in muscle restoration

Arginine can accelerate muscle restoration after training, improving the delivery of nutrients and hormones necessary to restore damaged muscle fibers.

G. Arginin and creatine

Arginine is one of the three amino acids necessary for the synthesis of creatine. Creatine plays an important role in energy metabolism in the muscles, increasing the level of ATP (adenosine triphosphate), the main source of energy for muscle contractions. Reception of arginine can indirectly improve muscle performance by increasing creatine synthesis.

H. Studies on the influence of arginine on muscle nutrition and performance

Numerous studies studied the influence of Arginine on muscle nutrition and performance. For example:

  • Studies have shown that Arginine additives can increase muscle strength and endurance.
  • Studies have shown that Arginine can improve muscle restoration after training.
  • Studies have shown that Arginine can increase the level of growth hormone (GR) and insulin.

IV. Form of Arginina and dosing

Arginine is available in the form of various additives:

A. L-Arginin

This is the most common form of Arginine. It is easily absorbed by the body and is effective for improving blood circulation and nutrition of muscles.

B. Arginine Alpha-Ketoglutarate (AAKG)

AAKG is an arginine compound with alpha-ketoglutarate, an intermediate product of the Krebs cycle (citric acid cycle). It is believed that AAKG is better absorbed and more effectively stimulates the synthesis of NO than L-Arginine.

C. Arginine Hydrochloride (Arginine HCL)

Arginine HCL is a salt of Arginine, which can be more stable and easier to soluble in water than L-Arginine.

D. Recommended dosage

The recommended dosage of Arginine varies depending on the purpose of the application and individual characteristics of the body. It is usually recommended to take from 3 to 6 grams of arginine per day, divided into several tricks.

  • To improve blood circulation: 3-6 grams per day.
  • To improve sports results: 5-10 grams per day, accepted 30-60 minutes before training.
  • For the treatment of erectile dysfunction: 2.5-5 grams per day.

It is important to start with a low dose and gradually increase it in order to evaluate tolerance.

V. Side effects and precautions

Arginine is usually considered safe for most people, but in some cases side effects may occur:

A. possible side effects

  • Gastrointestinal disorders: Nausea, vomiting, diarrhea, bloating and abdominal pain.
  • Reduced blood pressure: Especially in people with existing hypotension (low blood pressure).
  • Exacerbation of herpes: Arginine can stimulate the replication of herpes virus.
  • Interaction with drugs: Arginine can interact with some drugs such as nitrates (used to treat angina pectoris) and drugs to reduce blood pressure.
  • Allergic reactions: Rarely, but allergic reactions to Arginine are possible.

B. Precautions

  • Consult a doctor: Before taking Arginine, especially if you have any diseases or you take any medicine.
  • People with Herpes: Arginine can aggravate herpes, so people with herpes should take it with caution or avoid it at all.
  • People with low blood pressure: Arginine can reduce blood pressure, so people with hypotension should take it with caution.
  • People with kidney or liver diseases: Arginine is metabolized in the liver and is excreted by the kidneys, so people with diseases of these organs should take it with caution.
  • Pregnancy and breastfeeding: Arginine safety is not enough during pregnancy and breastfeeding, so it is recommended to avoid taking it during these periods.
  • Postoperative period: Arginine can affect blood coagulation, so it should be stopped taken a few days before surgery.

VI. Arginine: Interaction with other additives

Arginine is often combined with other additives to enhance its effects:

A. Citrullin

Citrullin is an amino acid that is converted into arginine in the body. Taking citrullin along with Arginine can increase the level of arginine in the blood more effective than taking only Arginine.

B. Creatine

As mentioned earlier, Arginin is one of the predecessors of creatine. The combined technique of arginine and creatine can improve muscle strength and endurance.

C. Beta-Alanin

Beta-Alanin is an amino acid that increases the level of carnosine in the muscles. Carnosine buffering lactic acid, reducing muscle fatigue. The combined reception of Arginine and beta-Alanina can improve sports results.

D. Antioxidants (vitamin C, vitamin E)

Nitrogen oxide (No) can be quickly laid out with free radicals. Reception of antioxidants, such as vitamin C and vitamin E, can protect NO from destruction and extend its effect.

VII. Arginine in clinical practice

Arginine is used in clinical practice to treat various diseases:

A. Treatment of wound damage

Arginine can accelerate wound healing, improving blood flow and stimulating collagen synthesis.

B. Treatment of burns

Arginine can improve recovery after burns, improving blood flow, stimulating protein synthesis and strengthening the immune system.

C. Treatment of immunodeficiency conditions

Arginine plays an important role in the immune function. Arginine supplements can improve the immune response in people with immunodeficiency states.

D. Treatment of infertility

Arginine can improve sperm mobility and increase the chances of conception.

VIII. Arginin: final comments

Arginine is an important amino acid that plays a key role in blood circulation, muscle nutrition and many other physiological processes. Arginine supplements can be useful for improving sports results, restoration of muscles, reducing blood pressure and treating various diseases. However, it is important to consult a doctor before taking Arginine in order to make sure that he is safe for you and does not interact with any medicines that you take.

IX. Future research

Despite the significant amount of studies on Arginine, future studies should be aimed at the following areas:

  • Determination of the optimal dosage and form of arginine for various purposes.
  • Studying the long -term effects of Arginine.
  • The study of the interaction of arginine with other nutrients and additives.
  • Determination of genetic factors affecting the response to Arginine.
  • The study of the role of Arginine in the prevention and treatment of various diseases.

Conducting these studies will better understand the role of Arginine in health and illness and optimize its use as a therapeutic agent.

X. Frequently asked questions (FAQ)

1. What is Arginine and why is it needed?

Arginine (L-argininin) is a seminocypsy, which is involved in various processes in the body, including the synthesis of nitrogen oxide (NO), which improves blood circulation and the synthesis of protein, which contributes to the growth and restoration of muscles.

2. What products do Arginine contain?

Arginine is found in meat, fish, eggs, dairy products, nuts, seeds and legumes.

3. What is the recommended dosage of Arginine?

The recommended dosage varies from 3 to 6 grams per day, divided into several techniques, depending on the purpose of use. For sports purposes, a higher dosage can be used-5-10 grams 30-60 minutes before training.

4. What side effects can occur when taking Arginine?

Possible side effects include gastrointestinal disorders, decreased blood pressure, aggravation of herpes and interaction with drugs.

5. Is it possible to take Arginine to pregnant and nursing women?

Arginine safety is not enough during pregnancy and breastfeeding, so it is recommended to avoid taking it during these periods.

6. What supplements can arginine combine?

Arginine can be combined with citrullin, creatine, beta-alanine and antioxidants to enhance its effects.

7. Who should avoid taking Arginine?

People with herpes, low blood pressure, kidney diseases or liver should take Arginine with caution or avoid it at all.

8. Can Arginin help with erectile dysfunction?

Yes, Arginine can improve the erectile function in some men, especially in those who have erectile dysfunction associated with impaired blood flow.

9. How does Arginine affect muscle growth?

Arginine improves blood flow to the muscles, stimulates the synthesis of protein and the release of growth hormones and insulin, which contributes to the growth and restoration of muscles.

10. Where to buy Arginine?

Arginine is available in pharmacies, sports nutrition stores and on the Internet in the form of food additives.

Xi. Glossary

  • Amino acid: An organic compound, which is a building block of proteins.
  • Polorcular amino acid: An amino acid that can be synthesized by the body, but in some situations it requires from the outside.
  • Vasodilation: Expansion of blood vessels.
  • Oxide Azote (No): A molecule playing the role of a vasodilator and participating in the regulation of blood flow and immune function.
  • Endothelial: Inner lining of blood vessels.
  • Hypertension: High blood pressure.
  • Hypotonia: Low blood pressure.
  • Growth hormone (GR): The hormone, which plays an important role in growth, restoration and metabolism.
  • Insulin: The hormone, which plays an important role in the metabolism of glucose and amino acids.
  • Protein synthesis: The process of the formation of proteins from amino acids.
  • Urea cycle: A metabolic process that removes toxic ammonia from the body.
  • Creatine: An organic compound, which plays an important role in energy metabolism in the muscles.
  • AAKG (arginine alpha-keglutarate): The connection of arginine with alpha-ketoglutarat.
  • Moving chroma: The pain in the legs when walking caused by insufficient blood flow.

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