Plant dietary supplements to strengthen the joints

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Plant dietary supplements to strengthen the joints: detailed analysis and review

Section 1: Fundamentals of joints of the joints and the role of plant additives

  1. Anatomy and joint physiology:

    • Determination of the joint: the connection place of two or more bones that ensures movement.
    • Main components:
      • Joint cartilage: smooth, elastic fabric covering the ends of the bones, reducing friction and shock -absorbing load. Consists of chondrocytes and intercellular matrix (collagen, proteoglycans, water).
      • Synovial fluid: a viscous fluid, a lubricating joint that feeds the cartilage and removes waste. Contains hyaluronic acid that ensures its viscosity and elasticity.
      • Synovial shell: a membrane lining a joint capsule producing a synovial fluid.
      • Joint capsule: dense fibrous shell surrounding the joint, providing stability and protection.
      • Blues: connecting fabrics connecting bones and stabilizing joints.
      • Meniski (in the knee joint): cartilage gaskets, depreciable load and improve the congruence of articular surfaces.
    • Movement mechanisms: sliding, rotation, flexion, extension, abduction, bringing, circular movement.
    • The role in maintaining mobility and function: ensuring the range of movements, shock -absorption of shocks, load distribution.

  2. Factors affecting the health of the joints:

    • Age: with age, cartilage is thinner, the production of synovial fluid decreases, and the risk of osteoarthritis increases.
    • Injuries: fractures, dislocations, ligaments, damage to meniscus can lead to degenerative changes in the joint.
    • Excess weight: increases the load on the joints, especially on the knee and hip, contributing to the development of osteoarthritis.
    • Lack of physical activity: leads to a weakening of muscles that support joints and a deterioration in the blood supply to the cartilage.
    • Excessive loads: repeated movements or high shock loads can cause cartilage damage and the development of inflammation.
    • Genetic predisposition: some people are more susceptible to joint diseases due to hereditary factors.
    • Inflammatory diseases: rheumatoid arthritis, systemic lupus erythematosus can cause inflammation and destruction of articular cartilage.
    • Improper nutrition: a deficiency of vitamins and minerals necessary for the health of the cartilage, and an excess of inflammatory products (sugar, processed products).
    • Smoking: worsens the blood supply to the cartilage and slows down the recovery processes.

  3. Joint diseases: overview of the main pathologies:

    • Osteoarthritis (OA): the most common joint disease, characterized by the destruction of cartilage, leading to pain, stiffness and limitation of movements. Risk factors: age, obesity, injury, genetic predisposition.
    • Rheumatoid arthritis (RA): Autoimmune disease characterized by chronic joint inflammation, leading to their destruction and deformation. Symptoms: pain, edema, stiffness, fatigue.
    • Gout: a metabolic disease caused by the accumulation of uric acid in the joints, leading to acute attacks of pain and inflammation. Risk factors: high consumption of meat and seafood, alcohol, obesity.
    • Bursis: inflammation of the synovial bags (brush), small with liquid of bags located between bones, tendons and muscles that reduce friction. Reasons: injuries, excessive loads, infections.
    • Tendinite: inflammation of the tendons connecting the muscles with bones. Reasons: excessive loads, repeated movements.
    • System Red lupus (SLE): Autoimmune disease that can affect various organs and systems, including joints.
    • Anquilizing spondylitis (ankylosing spondylitis): a chronic inflammatory disease that affects the spine and sacral and illegal joints, leading to limiting mobility and deformation.

  4. The role of plant dietary supplements in maintaining the health of the joints:

    • Action mechanisms:
      • Anti -inflammatory action: a decrease in the level of inflammatory mediators (cytokines, prostaglandins, leukotrienes).
      • Chondroprotective action: stimulation of the synthesis of collagen and proteoglycans, protection of cartilage from destruction.
      • Antioxidant effect: neutralization of free radicals that damage cartilage cells.
      • Anesthetic effect: a decrease in sensitivity to pain.
      • Improving microcirculation: improvement of blood supply to cartilage and other joint tissues.
    • Potential advantages:
      • Reducing pain and inflammation.
      • Improving joint mobility.
      • Slow down the progression of joint diseases.
      • Reducing the need for non -steroidal anti -inflammatory drugs (NSAIDs) having side effects.
    • Restrictions and warnings:
      • Are not a replacement for traditional treatment.
      • It is necessary to take into account individual tolerance and possible side effects.
      • It is important to consult a doctor before taking the appointment, especially in the presence of chronic diseases or taking other drugs.
      • Not all dietary supplements have proven effectiveness. It is necessary to choose products from trusted manufacturers with clinical research.
      • The dosage and duration of the reception must comply with the recommendations of the specialist.

Section 2: Basic plant ingredients used in the joints for joints

  1. Kurkuma (Curcuma longa):

    • Active component: Kurkumin.
    • The mechanism of action: powerful anti -inflammatory and antioxidant effects. Kurkumin inhibits the activity of enzymes involved in the inflammatory process (cyclooxygenase-2, lipoxygenase), and reduces the production of pro-inflammatory cytokines (interleukina-1, factor of tumor-alpha necrosis). Kurkumin also protects the cells from damage by free radicals.
    • Evidence of effectiveness: Numerous clinical studies have shown the effectiveness of turcumin in a decrease in pain and improving the function of joints in osteoarthritis.
    • Forms of release: capsules, tablets, powder, liquid extract.
    • Recommendations for use: dosage varies depending on the form of release and concentration of curcumin. It is usually recommended to take 500-2000 mg of curcumin per day, divided into several tricks. To improve the absorption of curcumin, it is recommended to take it with piperin (black pepper extract) or with fatty foods.
    • Precautions: Kurkumin can interact with some drugs, including anticoagulants and anti -agents. It is not recommended to take curcumin to pregnant and nursing women, as well as people with gallbladder diseases.

  2. Ginger (Zingiber Officinale):

    • Active components: ginerols, shogaols.
    • The mechanism of action: anti -inflammatory and analgesic effect. Ginger inhibits the synthesis of prostaglandins and leukotrienes, reducing inflammation and pain. Ginger also improves blood circulation and has antioxidant properties.
    • Evidence of effectiveness: the studies have shown that ginger can be effective in reducing pain and stiffness in osteoarthritis and rheumatoid arthritis.
    • Forms of release: capsules, tablets, powder, fresh root, extract.
    • Recommendations for use: dosage varies depending on the form of release. It is usually recommended to take 1-3 g of fresh ginger or 250-1000 mg of ginger extract per day.
    • Precautions: ginger can cause irritation of the gastrointestinal tract in some people. It is not recommended to take ginger in large doses to pregnant women and people with blood coagulation disorders.

  3. Boswellia serrata:

    • Active components: Boswellial acids.
    • The mechanism of action: anti -inflammatory action. Boswellic acids inhibit an enzyme 5-lipoxygenase, which is involved in the synthesis of leukotrienes, pro-inflammatory mediators. Boswellia also improves blood supply to the joints and has chondroprotective properties.
    • Evidence of effectiveness: Clinical studies have shown the effectiveness of Boswellion in a decrease in pain and improving the function of joints with osteoarthritis.
    • Forms of release: capsules, tablets, powder, cream.
    • Recommendations for use: The dosage varies depending on the form of the release and concentration of boswellic acids. It is usually recommended to take 300-500 mg of Boswellial extract per day, divided into several techniques.
    • Precautions: Boswellia can cause nausea, diarrhea and other gastrointestinal disorders in some people.

  4. Devil’s claw.

    • Active components: harpagosides.
    • The mechanism of action: anti -inflammatory and analgesic effect. The devil’s claw inhibits the synthesis of prostaglandins and leukotrienes, reducing inflammation and pain.
    • Evidence of effectiveness: the studies have shown that the devilish claw can be effective in reducing pain in osteoarthritis and back pain.
    • Forms of release: capsules, tablets, liquid extract, cream.
    • Recommendations for use: dosage varies depending on the form of the release and concentration of harpagosides. It is usually recommended to take 50-100 mg of harpagosides per day.
    • Precautions: a devilish claw can cause gastrointestinal disorders, such as diarrhea and nausea. It is not recommended to take a devilish claw to people with ulcerative disease of the stomach and duodenum, as well as pregnant and lactating women.

  5. Sables of the Swamp (Comarum Palustre):

    • Active components: flavonoids, tannins, organic acids.
    • The mechanism of action: anti -inflammatory, analgesic and chondroprotective effects. The swamp saber has antioxidant properties and improves blood circulation in the joints.
    • Evidence of effectiveness: traditionally used in folk medicine to treat joint diseases. Clinical studies are limited, but preliminary data indicate its potential efficiency.
    • Forms of release: tincture, capsules, cream.
    • Recommendations for use: dosage varies depending on the form of release. It is usually recommended to take a tincture of a swamp saber of 1 tablespoon 2-3 times a day.
    • Precautions: Sabor Square can cause allergic reactions in some people. It is not recommended to take a swamp saber to pregnant and lactating women.

  6. Nettle (urtica dioica):

    • Active components: flavonoids, vitamins, minerals.
    • The mechanism of action: anti -inflammatory and analgesic effect. Nettle contains compounds that inhibit the synthesis of pro -inflammatory cytokines. Nettle is also rich in silicon, which is necessary for the health of the cartilage.
    • Evidence of effectiveness: studies have shown that nettle can be effective in reducing pain in osteoarthritis.
    • Forms of release: capsules, tablets, tea, extract.
    • Recommendations for use: dosage varies depending on the form of release. It is usually recommended to take 300-600 mg of nettle extract per day.
    • Precautions: nettle can cause skin irritation in some people. It is not recommended to take nettle people with kidney diseases.

  7. Green -lipped mollusk (Perna Canaliculus):

    • Active components: omega-3 fatty acids, glucosaminoglycans.
    • The mechanism of action: anti -inflammatory and chondroprotective effects. Omega-3 fatty acids reduce inflammation, and glucosaminoglycans contribute to the restoration of cartilage.
    • Evidence of effectiveness: the studies have shown that green -towing mollusk can be effective in reducing pain and improving the function of joints in osteoarthritis.
    • Forms of release: capsules, tablets.
    • Recommendations for use: dosage varies depending on the form of release. It is usually recommended to take 1000-1500 mg extract of green-towing mollusk per day.
    • Precautions: green -lined mollusk can cause allergic reactions in people with allergies to seafood.

  8. White willow bark (Salix alba):

    • Active components: Salitsin.
    • The mechanism of action: analgesic and anti -inflammatory action. Salitsin turns into salicylic acid in the body, which has properties similar to aspirin.
    • Evidence of effectiveness: the studies have shown that the bark of Bele’s willow can be effective in reducing pain in osteoarthritis and back pain.
    • Forms of release: capsules, tablets, extract.
    • Recommendations for use: The dosage varies depending on the form of the release and concentration of salicycle. It is usually recommended to take 120-240 mg of salicin per day.
    • Precautions: Belaya willow can cause side effects similar to aspirin, such as irritation of the gastrointestinal tract and increased bleeding. It is not recommended to take the bark of willow white people with ulcerative disease of the stomach and duodenum, asthma, as well as pregnant and lactating women.

  9. Methyl sulfonylmetatan (MSM):

    • Active components: organic sulfur.
    • The mechanism of action: anti -inflammatory and chondroprotective effects. MSM contributes to the synthesis of collagen and proteoglycans necessary for the health of the cartilage. MSM also has antioxidant properties.
    • Evidence of effectiveness: studies have shown that MSM can be effective in reducing pain and improving the function of joints with osteoarthritis.
    • Forms of release: capsules, tablets, powder, cream.
    • Recommendations for use: dosage varies depending on the form of release. It is usually recommended to take 1-3 g of MSM per day.
    • Precautions: MSM is usually well tolerated, but in some people can cause gastrointestinal disorders.

  10. Avocado and soy in neo -smashed compounds (ASU):

    • Active components: phytosterols, vitamins, fatty acids.
    • The mechanism of action: anti -inflammatory and chondroprotective effects. ASU inhibits the synthesis of pro -inflammatory cytokines and stimulate the synthesis of collagen and proteoglycans.
    • Evidence of effectiveness: the studies have shown that ASU can be effective in reducing pain and improving the function of joints with osteoarthritis.
    • Forms of release: capsules.
    • Recommendations for use: Dosage usually is 300 mg ASU per day.
    • Precautions: ASU is usually well tolerated, but in some people can cause gastrointestinal disorders.

Section 3: Combined plant dietary supplements and synergism of action

  1. Advantages of combined dietary supplements:

    • Impact on various aspects of joint health (inflammation, pain, cartilage destruction).
    • Synergetic effect: enhancing the action of individual components in joint use.
    • Convenience: taking one product instead of several.

  2. Examples of effective combinations:

    • Kurkumin + Boswellion: increased anti -inflammatory action.
    • Glucosamine + chondroitin + MSM: a complex effect on cartilage and synovial fluid.
    • Ginger + Devil’s claw: enhanced analgesic effect.
    • ASU + curcumin: combined anti -inflammatory and chondroprotective effects.
    • Green lipped mollusk + MSM: combined effects on inflammation and cartilage.

  3. Factors that should be considered when choosing a combined dietary supplement:

    • Composition: the presence of ingredients with proven effectiveness.
    • Dosage: compliance of the dosages of individual components recommended.
    • Quality: The choice of products from trusted manufacturers with a good reputation.
    • Individual needs: taking into account the characteristics of the body and concomitant diseases.
    • Consultation with a doctor: Discussion with a doctor of the advisability of using a combined dietary supplement and possible interactions with other medicines.

Section 4: Scientific research and evidence -based base for plant dietary supplements

  1. Research methodology:

    • Randomized controlled studies (RCTs): Golden standard in assessing the effectiveness of medical interventions.
    • Meta analyzes: systematic reviews combining the results of several RCTs to obtain a more accurate assessment of the effect.
    • Observatory studies: Studies observing the outcome of a group of people without researchers’ intervention.
    • Studies in vitro and in vivo: laboratory studies conducted on cells and animals to study the mechanisms of action.

  2. Review of scientific research on individual plant ingredients:

    • Kurkumin: Numerous RCTs showed the effectiveness of turcumin in a decrease in pain and improving the function of the joints with osteoarthritis of the knee joint. Met-analyzes confirm these results.
    • Ginger: Studies have shown that ginger can be effective in reducing pain and stiffness with osteoarthritis.
    • Boswellion: Clinical studies showed the effectiveness of Boswellion in a decrease in pain and improving the function of joints in osteoarthritis.
    • Devil’s claw: studies have shown that the devilish claw can be effective in reducing pain in osteoarthritis and back pain.
    • ASU: Studies have shown that ASU can be effective in reducing pain and improving the joint function with osteoarthritis.
    • Green lipped mollusk: Studies have shown that green -lipped mollusk can be effective in reducing pain and improving the function of the joints with osteoarthritis.

  3. Criticism and restrictions on research:

    • Small sizes: some studies were carried out on a small number of participants, which reduces the statistical power of the results.
    • Differences in the methodology: differences in research design, dosages and evaluation criteria make it difficult to compare the results.
    • Subjectivity of assessments: assessment of pain and joint function can be subjective.
    • The bias of financing: some studies were financed by dietary supplements, which may affect the results.

  4. The need for further research:

    • Conducting larger and high -quality RCTs.
    • Study of long -term efficiency and safety of plant dietary supplements.
    • The study of the mechanisms of the action of plant ingredients at the molecular level.
    • Comparison of the effectiveness of plant dietary supplements with traditional methods of treating joint diseases.

Section 5: Practical recommendations for the selection and use of plant dietary supplements for joints

  1. Consultation with a doctor:

    • A prerequisite before taking any dietary supplement, especially in the presence of chronic diseases and taking other drugs.
    • Discussion with a doctor’s goals of taking dietary supplements, possible risks and side effects.
    • Obtaining recommendations for choosing the most suitable product and dosage.

  2. Choosing a quality product:

    • Search for products from trusted manufacturers with a good reputation.
    • Checking the availability of quality certificates (for example, GMP).
    • Reading customer reviews.
    • Paying attention to the composition of the product: the presence of ingredients with proven effectiveness and the absence of harmful additives.

  3. Dosage and reception mode:

    • Strict compliance with the doctor’s recommendations or packaging instructions.
    • The beginning of the reception with a minimum dose and its gradual increase if necessary.
    • Reception of dietary supplements at the same time every day to maintain a stable concentration in the blood.
    • Accounting for interaction with other medicines and food.

  4. Evaluation of effectiveness:

    • Regular monitoring of the condition of the joints: tracking pain, shaving, mobility.
    • Comparison of the condition before and after the start of admission of dietary supplements.
    • Discussion of the results with a doctor to adjust the dosage or replacement of the product if necessary.
    • Taking into account the fact that the effect of plant dietary supplements can be gradual and require long -term intake (several weeks or months).

  5. Combined approach:

    • The combination of the use of plant dietary supplements with other methods of maintaining joint health:
      • Exercise: strengthening muscles supporting joints, improving blood circulation.
      • Proper nutrition: providing the body with the necessary nutrients for the health of cartilage and bones.
      • Maintaining healthy weight: reducing the load on the joints.
      • Physiotherapy: Improving the mobility of the joints and a decrease in pain.

Section 6: Safety and side effects of plant dietary supplements

  1. General principles of security:

    • Most of the plant dietary supplements are considered safe subject to the recommended dosages.
    • However, some people may have side effects.
    • It is important to consider individual tolerance and possible interactions with other drugs.

  2. Side effects of individual plant ingredients:

    • Kurkumin: It can cause a disorder of the gastrointestinal tract (nausea, diarrhea).
    • Ginger: can cause heartburn and irritation of the stomach.
    • Boswellia: can cause nausea, diarrhea and other gastrointestinal disorders.
    • Devil’s claw: can cause gastrointestinal disorders, headache and allergic reactions.
    • Nettle: can cause skin irritation.
    • Green lipped mollusk: can cause allergic reactions in people with allergies to seafood.
    • Belea willow bark: can cause side effects similar to aspirin, such as irritation of the gastrointestinal tract and increased bleeding.
    • MSM: It can cause a disorder of the gastrointestinal tract.

  3. Interaction with drugs:

    • Plant dietary supplements can interact with some drugs by changing their effect or enhancing side effects.
    • It is especially important to take into account the interaction with anticoagulants, anti -signs, antidepressants and drugs for the treatment of diabetes.
    • It is necessary to inform the doctor about all the dietary supplements in order to avoid undesirable interactions.

  4. Contraindications:

    • Pregnancy and breastfeeding: many plant dietary supplements are not recommended for pregnant and lactating women due to lack of security data.
    • Diseases of the gastrointestinal tract: some plant dietary supplements can cause irritation of the stomach and intestines, so people with peptic ulcer, gastritis and other gastrointestinal diseases should be avoided.
    • Allergic reactions: people with allergies to certain plants should avoid dietary supplements containing these plants.
    • Diseases of the liver and kidneys: some plant dietary supplements can exert a load on the liver and kidneys, so they should be taken with caution to people with diseases of these organs.

  5. Side effects message:

    • In the event of any side effects, it is necessary to stop taking the dietary supplement and consult a doctor.
    • A message about side effects helps to identify potential risks and improve the safety of dietary supplements.

Section 7: The future of plant dietary supplements for joint health

  1. Development of scientific research:

    • In -depth study of the mechanisms of the action of plant ingredients at the molecular level.
    • Conducting larger and high -quality clinical research to confirm efficiency and safety.
    • Development of new methods of delivery of plant ingredients to the joints to increase their bioavailability.
    • The study of the influence of plant dietary supplements on the prevention of joint diseases.

  2. New plant ingredients:

    • Search for new plant sources with potential health benefits.
    • The study of traditional medicine and the experience of using plants for the treatment of joint diseases.
    • Development of new dietary supplements based on a combination of famous and new plant ingredients.

  3. Personalized approach:

    • Accounting for genetic characteristics, lifestyle and concomitant diseases when choosing plant dietary supplements.
    • Development of individual treatment programs including dietary supplements, physical exercises and diet.
    • The use of biomarkers to assess the efficiency and safety of plant dietary supplements.

  4. Regulatory policy:

    • Strengthening control over the quality and safety of plant dietary supplements.
    • Development of clear standards for the production and marking of dietary supplements.
    • Informing consumers about the advantages and risks of using plant dietary supplements.
    • Support for scientific research in the field of plant dietary supplements.

  5. Integration with traditional medicine:

    • Integration of plant dietary supplements in the complex treatment of joint diseases.
    • Training in doctors and other medical workers with the principles of the use of plant dietary supplements.
    • The joint work of doctors and specialists in herbal medicine for the development of optimal treatment schemes.

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