New dietary supplements for the brain: innovative developments

Section 1: Cognitive landscape of the XXI century: calls and opportunities for the brain

1. 1. The evolution of mental loads: from the hunter-gatherer to the digital nomad. Initially, the human brain was formed in conditions of survival in the wild, where the key was orientation skills, memorizing the location of resources, quick decision -making in dangerous situations and effective social interaction in small groups. The modern world imposes completely different requirements to the brain: processing huge amounts of information, multitasking, constant training in new skills, adaptation to rapidly changing technologies and maintaining productivity in the conditions of information overload. Analysis of historical changes in the requirements for cognitive functions, from the need to memorize animal migration routes to processing large data in business. Comparison of cognitive loads in various professions (from physical labor workers to specialists in the field of IT and science). Consideration of the influence of globalization and digitalization on cognitive functions and mental health.
2. 2. Stress, lack of sleep and information overload: the main enemies of the modern brain. Chronic stress leads to excessive production of cortisol, which damages the neurons of the hippocampus responsible for memory and training. The lack of sleep violates the processes of memory consolidation and worsens cognitive functions, such as attention, concentration and decision -making. Information overload leads to a decrease in the ability to filter information, distraction and cognitive fatigue. The mechanisms of the influence of chronic stress on neurogenesis and synaptic plasticity. Analysis of the relationship between lack of sleep and the risk of developing neurodegenerative diseases, such as Alzheimer’s disease. Consideration of stress and information overload management methods, including meditation, Mind Fulness and time management techniques.
3. 3. Age -related brain changes: natural processes and slowdown. With age, there is a decrease in the volume of the brain, a decrease in the number of neurons and synapses, a deterioration in the blood supply to the brain and a decrease in the level of neurotransmitters. These changes can lead to a deterioration in memory, attention, speed of thinking and other cognitive functions. Nevertheless, there are ways to slow down these processes, including physical activity, cognitive training, healthy nutrition and intake of dietary supplements that support brain health. The role of genetic factors and lifestyle in the rate of aging of the brain. Review of research on the influence of physical exercises on neurogenesis and cognitive functions in old age. Consideration of the concept of a “cognitive reserve” and ways to increase it.
4. 4. Neuroplasticity: the ability of the brain to adapt and learning throughout life. Neuroplasticity is the ability of the brain to change its structure and functions in response to experience. This ability underlies training, memory and adaptation to new conditions. Stimulation of neuroplasticity through cognitive training, studying new languages, music classes and other activities can improve cognitive functions at any age. Neuroplasticity mechanisms at the cellular and molecular levels (synaptogenesis, neurogenesis, LTP, LTD). A review of the methods of stimulation of neuroplasticity, including transcranial magnetic stimulation (TMS) and transcranial stimulation of direct current (TDCS). Consideration of the role of neurotrophic factors, such as BDNF, in maintaining neuroplasticity.
5. 5. Diagnosis of cognitive disorders: from subjective sensations to objective tests. Timely diagnosis of cognitive impairment is crucial for the development of an effective strategy for treating and improving the quality of life. There are various diagnostic methods, including neuropsychological testing, neuroizualization (MRI, PET) and analysis of biomarkers in the blood and cerebrospinal fluid. The development of new diagnostic methods based on the analysis of data from wearable devices and the use of artificial intelligence can improve the accuracy and accessibility of the diagnosis of cognitive impairment. Description of various neuropsychological tests for evaluating memory, attention, executive functions and speech. Consideration of the role of neuroimaging in the identification of structural and functional changes in the brain. An overview of biomarkers associated with the risk of developing Alzheimer’s disease and other neurodegenerative diseases.

Section 2: New horizons: innovative dietary supplements for the brain

2. 1. New generation nootropes: molecular mechanisms and clinical studies. Classic nootropics, such as piracetams and cinarine, have limited effectiveness and can cause side effects. New nootropes are developed taking into account modern knowledge about the molecular mechanisms of the brain and have higher selectivity and effectiveness. Examples of new nootropes include peptide nootropics, drugs affecting the level of neurotransmitters and substances that stimulate neurogenesis. A detailed description of the molecular mechanisms of the action of promising nootropics. Overview of the results of clinical studies of new nootropics in various groups of patients (healthy people, patients with cognitive disorders, athletes). Discussion of potential risks and side effects of new nootropics.
3. 2. Plant adaptogens: ancient knowledge and modern technologies. Plant adaptogens, such as Rodiola Pink, Eleutherococcus and Ashvaganda, have the ability to increase the body’s resistance to stress and improve cognitive functions. Modern technologies allow you to extract the most active components from plants and create standardized extracts with high bioavailability. Clinical studies confirm the effectiveness of adaptogens in improving memory, attention, concentration and reducing anxiety. The mechanisms of the action of plant adaptogens on the hormonal balance, the immune system and the nervous system. A review of clinical studies on the influence of specific adaptogens on cognitive functions and stress resistance. Discussion of safety and potential interactions of plant adaptogens with other drugs.
4. 3. Neurometabolic booster: optimization of energy metabolism in the brain. The brain consumes about 20% of all the energy of the body, so the optimization of energy metabolism is crucial for maintaining its health and functioning. Neurometabolic booster, such as Q10 coenzyme, alpha-lipoic acid and creatine, improve energy metabolism in brain cells, protect neurons from oxidative stress and support cognitive functions. The mechanisms of action of neurometabolic booster on mitochondria and antioxidant protection. A review of clinical studies on the influence of neurometabolic booster on cognitive functions and energy level. Discussion of potential risks and side effects of neurometabolic booster.
5. 4. Prebiotics and probiotics: the axis of the “intestines-Moscow” and cognitive health. The axis of the “intestines-mozg” is a biparts between the intestinal microbiota and the brain. Microbiota imbalance can affect cognitive functions, mood and behavior. Prebiotics and probiotics support the health of intestinal microbiots and can improve cognitive functions by reducing inflammation, improving the production of neurotransmitters and modulating the immune system. The mechanisms of the effect of intestinal microbiota on the brain through the vagus nerve, the immune system and the production of neurotransmitters. A review of clinical studies on the influence of prebiotics and probiotics on cognitive functions, mood and anxiety. Discussion of the choice of correct probiotic strains to improve cognitive functions.
6. 5. Liposomal forms: increased bioavailability and effectiveness of dietary supplements. Liposomes are microscopic spheres consisting of phospholipids that are used to deliver drugs and dietary supplements. Liposomal forms of dietary supplements have increased bioavailability, since liposomes protect active substances from destruction in the gastrointestinal tract and facilitate their penetration through cell membranes. Liposomal forms of vitamins, minerals and plant extracts can be more effective than conventional forms. The mechanisms of the action of lipos in the delivery of active substances to brain cells. Comparison of bioavailability of liposomal and ordinary forms of dietary supplements. Review of studies on the use of liposomal dietary supplements to improve cognitive functions.
7. 6. Nutrigenomy: a personalized approach to nutrition and cognitive health. Nutrigenomy studies the effect of genetic factors on the body’s reaction to food and nutrients. Analysis of the human genetic profile allows you to identify individual needs for nutrients and develop a personalized diet and dietary supplement for optimizing cognitive functions. The possibilities and restrictions of nutritigenomic testing. Examples of genetic polymorphisms affecting cognitive functions and the need for nutrients. Discussion of ethical and social aspects of nutrigenomy.
8. 7. The future of dietary supplements for the brain: nanotechnology and artificial intelligence. Nanotechnology and artificial intelligence open up new opportunities for the development of dietary supplements for the brain. Nanoparticles can be used to deliver drugs and dietary supplements directly to the brain, overcoming the hematoencephalic barrier. Artificial intelligence can be used to analyze big data and identify new targets to affect the brain and develop new, more effective dietary supplements. Prospects for using nanoparticles for targeted delivery of drugs and dietary supplements to the brain. The role of artificial intelligence in the development of new dietary supplements and predicting their effectiveness. Discussion of ethical and regulatory issues related to the use of nanotechnologies and artificial intelligence in the development of dietary supplements.

Section 3: Safety and effectiveness: how to choose the right dietary supplement for the brain

9. 1. Clinical tests: Golden standard for assessing the effectiveness of dietary supplements. Clinical trials are a prerequisite for confirming the efficiency and safety of dietary supplements. Randomized, placebo-controlled clinical trials allow us to evaluate the effect of dietary supplement on cognitive functions and identify possible side effects. Criteria for assessing the quality of clinical tests (sample size, research design, statistical analysis). Review of clinical research databases (Pubmed, Cochrane Library). The importance of a critical assessment of the results of clinical research and accounting for possible displacements.
10. 2. Quality and purity: safety guarantees and dietary supplements. The quality and purity of dietary supplements are crucial for ensuring their safety and efficiency. It is important to choose dietary supplements from reliable manufacturers who use high -quality raw materials and comply with production standards (GMP). Independent laboratories can test dietary supplements to confirm their composition and lack harmful impurities. The role of GMP certification (good manufactoring practice) in ensuring the quality of dietary supplements. Methods of analysis of dietary supplements to determine their composition and the presence of harmful impurities (heavy metals, pesticides). The importance of choosing dietary supplements from manufacturers with good reputation and positive reviews.
11. 3. Individual features: taking into account age, health status and drugs taken. The choice of dietary supplement for the brain should be individual and take into account the age, health status, medications taken and other factors. Before taking a dietary supplement, it is necessary to consult a doctor in order to exclude possible contraindications and interactions with other drugs. The influence of age on the efficiency and safety of dietary supplements. Accounting for the state of health (the presence of chronic diseases, allergies) when choosing a dietary supplement. The importance of consulting a doctor before starting a dietary supplement.
12. 4. Dosage and reception mode: optimal strategies to achieve the maximum effect. The dosage and reception mode of dietary supplements can affect its effectiveness. It is important to comply with the recommendations of the manufacturer and, if necessary, adjust the dosage under the supervision of a doctor. Some dietary supplements are best taken in the morning to increase energy and concentration, others in the evening to improve sleep and relaxation. The effect of dosage on the effectiveness and safety of dietary supplements. The optimal reception mode of dietary supplements (time of day, intake with food or on an empty stomach). The importance of compliance with the recommendations of the manufacturer and the doctor.
13. 5. Side effects and interactions: what you need to know before starting dietary supplements. Bades, like any other substances, can cause side effects and interact with other drugs. It is important to know about possible side effects and interactions and inform the doctor about them. In the event of side effects, it is necessary to stop taking the dietary supplement and consult a doctor. The most common side effects of dietary supplements for the brain (headache, nausea, insomnia). Examples of interactions of dietary supplements with drugs (anticoagulants, antidepressants). The importance of informing the doctor about the dietary supplements.
14. 6. Legal aspects: regulation of the market of baskets and protecting consumer rights. The dietary supplement market is regulated less strictly than the drug market. It is important to know about your rights as a consumer and choose dietary supplements from manufacturers who comply with the legislation. In case of problems with quality or safety of dietary supplements, you can contact the consumer protection authorities. Features of the regulation of the market of the baskets in various countries. The role of consumer protection authorities in protecting the rights of consumers of dietary supplements. The importance of choosing dietary supplements from manufacturers who comply with the legislation and provide complete information about the product.

Section 4: Practical recommendations: Integration of dietary supplements into a healthy lifestyle to maintain cognitive health

15. 1. The basics of a healthy lifestyle: nutrition, sleep, physical activity, social interaction. Bades can be useful for maintaining cognitive health, but they are not a replacement of a healthy lifestyle. Balanced nutrition, sufficient sleep, regular physical activity and active social interaction – this is the basis of cognitive health. The role of proper nutrition in maintaining brain health (necessary vitamins, minerals, antioxidants). The effect of sleep on cognitive functions and mental health. The benefits of physical activity for the brain (improvement of blood circulation, stimulation of neurogenesis). The importance of social interaction to maintain cognitive functions and mental health.
16. 2. Cognitive training: exercises for the brain and the development of new skills. Cognitive training is exercises aimed at improving memory, attention, speed of thinking and other cognitive functions. The study of new languages, a game of chess, a solution to puzzles and other activities that require mental stress can stimulate neuroplasticity and improve cognitive functions. Examples of cognitive training to improve memory, attention and executive functions. The role of cognitive training in maintaining a cognitive reserve. The importance of the regularity and diversity of cognitive training.
17. 3. Stress management: relaxation techniques, meditation, Mind Fulness. Chronic stress negatively affects cognitive functions, so it is important to be able to control stress. Relaxation techniques, meditation and Mindfulnes help reduce stress, improve mood and increase concentration. The mechanisms of action of the techniques of relaxation, meditation and Mayland Fulness on the brain and the nervous system. Review of various stress management techniques (breathing exercises, progressive muscle relaxation, auto -training). The importance of the regular practice of stress management techniques.
18. 4. Social activity: communication, volunteering, participation in interest groups. Active social interaction supports cognitive functions and mental health. Communication with friends and family, volunteering and participation in interest groups stimulate the brain, improve mood and reduce the risk of dementia. The influence of social isolation on cognitive functions and mental health. The benefits of volunteering for the brain (improvement of cognitive functions, increased self -esteem). The importance of maintaining active social life.
19. 5. Personalized approach: Development of an individual strategy for maintaining cognitive health. Maintaining cognitive health is an individual process that requires accounting for personal characteristics, needs and goals. The development of an individual strategy, including a healthy lifestyle, cognitive training, stress management, social activity and intake of dietary supplements, allows you to achieve maximum effect and preserve cognitive functions for many years. The importance of self -observation and tracking progress. Adaptation of a strategy to changing needs and circumstances. The role of a doctor and other specialists in the development and implementation of an individual strategy for maintaining cognitive health.

Section 5: Research Prospects: The future of cognitive improvement using dietary supplements

20. 1. Microbioma studies: deepening the understanding of the effects of intestinal microbiots on the brain. Future studies will be aimed at deepening the understanding of the mechanisms of the effect of intestinal microbiota on the brain and the development of new prebiotics and probiotics to improve cognitive functions and mental health. Determination of specific strains of probiotics that have the greatest effect on cognitive functions. Development of new methods of analysis of microbioma to identify individual characteristics and predict the risk of developing cognitive disorders. Studies of the influence of the diet on microbia and cognitive functions.
21. 2. Studies of neuro -sparrow: Development of new means to protect the brain from inflammation. Neuro -sparrowing plays an important role in the development of many neurodegenerative diseases. Future studies will be aimed at developing new means to protect the brain from inflammation and slowing down the progression of these diseases. Identification of key molecules involved in neuro -sleeping. Development of new drugs and dietary supplements inhibiting neuro. Studies of the influence of the diet and lifestyle on neuroigation.
22. 3. Neurogenesis studies: stimulation of the formation of new neurons to improve cognitive functions. Neurogenesis is the process of the formation of new neurons in the brain. Future studies will be aimed at stimulating neurogenesis to improve cognitive functions and restore damaged neurons. Identification of factors stimulating neurogenesis. Development of new drugs and dietary supplements stimulating neurogenesis. Studies of the influence of physical activity and cognitive training on neurogenesis.
23. 4. Using large data and artificial intelligence: identifying new targets and developing personalized dietary supplements. The use of large data and artificial intelligence will identify new targets to affect the brain and develop personalized dietary supplements, taking into account the individual genetic and physiological characteristics of each person. Analysis of genomic data to identify genetic factors affecting cognitive functions. Development of artificial intelligence algorithms to predict the effectiveness of dietary supplements. The use of wearable devices for monitoring cognitive functions and evaluating the effectiveness of dietary supplements.
24. 5. Ethical and social issues: discussing the consequences of using dietary supplements for cognitive improvement. The use of dietary supplements for cognitive improvement raises important ethical and social issues that need to be discussed and solved. Equality of access to cognitive improvements. Potential abuse of dietary supplements for cognitive improvement. The influence of cognitive improvement on social inequality. The importance of informed consent and responsible use of dietary supplements.